Identification of the cystic fibrosis gene: cloning and characterization of complementary DNA.
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Summary
A deletion of three base pairs that results in the omission of a phenylalanine residue at the center of the first predicted nucleotide-binding domain was detected in CF patients.
- Type
- article
- Published
- 1989-09-08
- Cited by
- 4,478
- References
- 95
- OpenAlex
- https://openalex.org/W2039599894
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:84566748
Keywords
Nucleotide, DNA, Biology, Gene, Molecular biology
References
- Chloride and potassium channels in cystic fibrosis airway epithelia
- Molecular characterization of the oligopeptide permease of Salmonella typhimurium.
- Phosphate-specific transport system of Escherichia coli: nucleotide sequence and gene-polypeptide relationships
- Identification and regional localization of DNA markers on chromosome 7 for the cloning of the cystic fibrosis gene.
- Distantly related sequences in the alpha‐ and beta‐subunits of ATP synthase, myosin, kinases and other ATP‐requiring enzymes and a common nucleotide binding fold.
- Mapping of gene transcripts by nuclease protection assays and cDNA primer extension.
- Nucleotide sequence of the structural genes for an anion pump. The plasmid-encoded arsenical resistance operon.
- The nucleotide sequences of the rbsD, rbsA, and rbsC genes of Escherichia coli K12.
- Recombinations between IRP and cystic fibrosis.
- Nucleotide sequence of the btuCED genes involved in vitamin B12 transport in Escherichia coli and homology with components of periplasmic-binding-protein-dependent transport systems
- Adenylyl cyclase amino acid sequence: possible channel- or transporter-like structure.
- Domainal evolution of a prokaryotic DNA repair protein and its relationship to active-transport proteins
- Nucleotide sequence of Xenopus C-raf coding region.
- The nodI gene product of Rhizobium leguminosarum is closely related to ATP-binding bacterial transport proteins; nucleotide sequence analysis of the nodI and nodJ genes.
- Identification of the cystic fibrosis gene: chromosome walking and jumping.
- Altered regulation of airway epithelial cell chloride channels in cystic fibrosis.
- Multiple genes encode the human Na+,K+-ATPase catalytic subunit.
- A simple method for displaying the hydropathic character of a protein.
- Cystic fibrosis decreases the apical membrane chloride permeability of monolayers cultured from cells of tracheal epithelium.
- Complete nucleotide sequence and identification of membrane components of the histidine transport operon of S. typhimurium
Cited by
- Tuberous Sclerosis Complex: Genetic Aspects
- DNA-Based Techniques in Clinical Biochemistry: A Beginner's Guide to Theory and Practice
- Cystic fibrosis transmembrane conductance regulator: nucleotide binding to a synthetic peptide
- Characterization of trypsinogens 1 and 2 in two human pancreatic adenocarcinoma cell lines; CFPAC‐1 and CAPAN‐1
- A cystic fibrosis patient with the nonsense mutation G542X and the splice site mutation 1717-1.
- Classification of membrane transporters.
- Oxidants and respiratory tract epithelial injury: pathogenesis and strategies for therapeutic intervention.
- Structure and function of the B and D genes of the Actinobacillus actinomycetemcomitans leukotoxin complex.
- Identification of sequences of chromosome 7 that are expressed in sweat gland epithelial cells
- Protein joins transport family
- CFTR three-dimensional structure.
- Cystic fibrosis genetic counselling: an audit of counsellees and their at-risk relatives
- High-density multiplex detection of nucleic acid sequences: oligonucleotide ligation assay and sequence-coded separation.
- P-glycoprotein homologues.
- Molecular analysis of X-linked adrenoleukodystrophy patients.
- Functional Dissection of P-glycoprotein Nucleotide-binding Domains in Chimeric and Mutant Proteins
- A missense mutation (F87L) in exon 3 of the cystic fibrosis transmembrane conductance regulator gene
- ABC transporters: bacterial exporters
- Ceramide-enriched membrane domains in infectious biology and development.
- Functional characterization of a glycine 185-to-valine substitution in human P-glycoprotein by using a vaccinia-based transient expression system.
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