A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid β
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Summary
An anatomically distinct clearing system in the brain that serves a lymphatic-like function is described and may have relevance for understanding or treating neurodegenerative diseases that involve the mis-accumulation of soluble proteins, such as amyloid β in Alzheimer's disease.
- Type
- article
- Published
- 2012-08-15
- Cited by
- 5,463
- References
- 59
- Access
- Open access
- OpenAlex
- https://openalex.org/W2167183660
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:18653970
Keywords
Glymphatic system, Parenchyma, Interstitial fluid, Cerebrospinal fluid, Pathology
References
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- Widespread spinal cord transduction by intrathecal injection of rAAV delivers efficacious RNAi therapy for amyotrophic lateral sclerosis.
- Selenoprotein P and apolipoprotein E receptor‐2 interact at the blood‐brain barrier and also within the brain to maintain an essential selenium pool that protects against neurodegeneration
- CSF and Plasma Amyloid-β Temporal Profiles and Relationships with Neurological Status and Mortality after Severe Traumatic Brain Injury
- Inspiration Is the Major Regulator of Human CSF Flow
- From sewer to saviour — targeting the lymphatic system to promote drug exposure and activity
- The established and emerging roles of astrocytes and microglia in amyotrophic lateral sclerosis and frontotemporal dementia
- Cisternostomy for Traumatic Brain Injury: Pathophysiologic Mechanisms and Surgical Technical Notes.
- Optimal-mass-transfer-based estimation of glymphatic transport in living brain
- Autologous transplantation of intestine-isolated glia cells improves neuropathology and restores cognitive deficits in β amyloid-induced neurodegeneration
- Potential Pathways for CNS Drug Delivery Across the Blood-Cerebrospinal Fluid Barrier
- Factors determining the density of AQP4 water channel molecules at the brain–blood interface
- Modulators of IgG penetration through the blood-brain barrier: Implications for Alzheimer's disease immunotherapy
- P. acnes-Driven Disease Pathology: Current Knowledge and Future Directions
- Implications of neurovascular uncoupling in functional magnetic resonance imaging (fMRI) of brain tumors
- The role of T cells in the pathogenesis of Parkinson’s disease
- Acetazolamide Mitigates Intracranial Pressure Spikes Without Affecting Functional Outcome After Experimental Hemorrhagic Stroke
- PDGFRβ Cells Rapidly Relay Inflammatory Signal from the Circulatory System to Neurons via Chemokine CCL2.
- Boundary waves in a microfluidic device as a model for intramural periarterial drainage.
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