The "perivascular pump" driven by arterial pulsation is a powerful mechanism for the distribution of therapeutic molecules within the brain.

Keywords

Distribution (mathematics), Liposome, Globus pallidus, Blood–brain barrier, Perivascular space

References

• Capillary and arterial cerebral amyloid angiopathy in Alzheimer's disease: defining the perivascular route for the elimination of amyloid β from the human brainStephen Preston, P. V. Steart, James S. Wilkinson — 2003
• Central Nervous System Structures Labelled from the Testis Using the Transsynaptic Viral Tracing TechniqueIda Gerendai, I. E. Tóth, Zsolt Boldogkői — 2000
• The Human Brain and Spinal CordLennart Heimer — 1983
• Cerebral amyloid angiopathy: amyloid beta accumulates in putative interstitial fluid drainage pathways in Alzheimer's disease.Roy O. Weller, Adrian Massey, Tracey A. Newman — 1998
• Neuron to neuron transmission of herpes simplex virus. Transport of virus from skin to brainstem nuclei.Krister Kristensson, Inger Nennesmo, L. Persson — 1982
• Continuous low-dose treatment with brain-derived neurotrophic factor or neurotrophin-3 protects striatal medium spiny neurons from mild neonatal hypoxia/ischemia: a stereological study.Kerry A. Galvin, Dorothy E. Oorschot — 2003
• Pseudorabies Virus Membrane Proteins gI and gE Facilitate Anterograde Spread of Infection in Projection- Specific Neurons in the RatPaul J. Husak, Timothy Kuo, Lynn W. Enquist — 2000
• Bulk flow of interstitial fluid after intracranial injection of blue dextran 2000.Helen F. Cserr, Louis H. Ostrach — 1974
• Cerebral amyloid angiopathy plays a direct role in the pathogenesis of Alzheimer's disease. Pro-CAA position statement.James A. R. Nicoll, Masahito Yamada, Janusz Frackowiak — 2004
• Heparin coinfusion during convection-enhanced delivery (CED) increases the distribution of the glial-derived neurotrophic factor (GDNF) ligand family in rat striatum and enhances the pharmacological activity of neurturin.John F. Hamilton, Paul F. Morrison, Michael Y. Chen — 2001
• Convection-enhanced delivery of AAV-2 combined with heparin increases TK gene transfer in the rat brainJohn Nguyen, Rosario Sánchez‐Pernaute, Janet Cunningham — 2001
• In vivo PET imaging of gene expression in Parkinsonian monkeys.Jamie L. Eberling, Janet Cunningham, Phillip Pivirotto — 2003
• Recent advances in the use of neurotropic viruses for circuit analysis.Lynn W. Enquist, J. Patrick Card — 2003
• Differential and persistent expression patterns of CNS gene transfer by an adeno-associated virus (AAV) vector.Thomas J. McCown, Xiao Xiao, Juan Li — 1996
• Scalable Purification of Adeno-Associated Virus Type 2, 4, or 5 Using Ion-Exchange ChromatographyNikola Kaludov, Beverly Handelman, John A. Chiorini — 2002
• Evidence for a 'paravascular' fluid circulation in the mammalian central nervous system, provided by the rapid distribution of tracer protein throughout the brain from the subarachnoid space.Marshall L. Rennels, Thomas F. Gregory, O R Blaumanis — 1985
• Tropism of AAV‐2 vectors for neurons of the globus pallidusLiliane Tenenbaum, Fabrice Jurysta, Angelike Stathopoulos — 2000
• Arterial Pulsation-driven Cerebrospinal Fluid Flow in the Perivascular Space: A Computational ModelLynne E. Bilston, David F. Fletcher, Andrew Brodbelt — 2003
• Tight regulation from a single tet-off rAAV vector as demonstrated by flow cytometry and quantitative, real-time PCRLei jiang, S Rampalli, David George — 2004
• A method for microscopic studies of cerebral angioarchitecture and vascular-parenchymal relationships, based on the demonstration of 'paravascular' fluid pathways in the mammalian central nervous system.Thomas F. Gregory, Marshall L. Rennels, O R Blaumanis — 1985

Cited by

• Gene therapy for Parkinson’s disease: where are we now and where are we going?А. С. Рахимкулов, N K Borisova, Г. Н. Аверцев — 2010
• Strong Cortical and Spinal Cord Transduction After AAV7 and AAV9 Delivery into the Cerebrospinal Fluid of Nonhuman Primatesmichelp — 2013
• Intranasal Targeting of Neuropeptides to the Central Nervous System: Evaluation of Pharmacokinetics, Pharmacodynamics, and a Novel Vasoconstrictor FormulationShyeilla V. Dhuria — 2009
• Développement de vecteurs lentiviraux régulables pour le transfert de gène dans le système nerveux centralLahouari Amar — 2007
• The Glymphatic System – A Beginner's GuideNadia Aalling, Anne Sofie Finmann Munk, Iben Lundgaard — 2015
• Methodology and effects of repeated intranasal delivery of DNSP-11 in a rat model of Parkinson’s diseaseMallory J. Stenslik, Lisa F. Potts, James Sonne — 2015
• Studies On The Fluid Mechanics And Mass Transfer In Neural Drug DeliveryPeng Wang — 2011
• Factors involved in the design of nasal delivery systems for peptides and proteinsA. Muñoz-Cernada, Mirna Fernández-Cervera, Julio Rodríguez — 2013
• Controlled dissemination of AAV vectors in the primate brain.Vanja Varenika, Adrian P. Kells, Francisco Valles — 2009
• Convection‐Enhanced Drug Delivery to the Brain: Therapeutic Potential and Neuropathological ConsiderationsNeil U. Barua, Steven S. Gill, Seth Love — 2014
• Pioneering Preclinical Research in Diffuse Intrinsic Pontine Glioma: Towards New Treatment StrategiesViola Caretti — 2012
• Convection-enhanced delivery of liposomes to primate brain.Michal T. Krauze, John Forsayeth, Dali Yin — 2009
• Cannula placement for effective convection-enhanced delivery in the nonhuman primate thalamus and brainstem: implications for clinical delivery of therapeutics.Dali Yin, R. Mark Richardson, Massimo S. Fiandaca — 2010
• Convection-enhanced delivery for glioblastoma: targeted delivery of antitumor therapeutics.Timothy H. Ung, Hani Malone, Peter Canoll — 2015
• Intranasal delivery: circumventing the iron curtain to treat neurological disordersYongjun Jiang, Yun Li, Xinfeng Liu — 2015
• Intranasal gene delivery for treating Parkinson’s disease: overcoming the blood–brain barrierAmirah E.-E. Aly, Barbara L. Waszczak — 2015
• Interaction between therapeutic interventions for Alzheimer’s disease and physiological Aβ clearance mechanismsChristopher D. Morrone, Mingzhe Liu, Sandra E. Black — 2015
• Imaging of Cells and Nanoparticles: Implications for Drug Delivery to the BrainKatica Stojanov, Inge S. Zuhorn, Rudi Dierckx — 2012
• Intranasal delivery of therapeutic proteins for neurological diseasesFrancesca Malerba, Francesca Paoletti, Simona Capsoni — 2011
• Accessing the Brain: The Nose may Know the WayPer G. Djupesland, Ramy Mahmoud, John Messina — 2013

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