From sewer to saviour — targeting the lymphatic system to promote drug exposure and activity
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Summary
The lymphatic system serves an integral role in fluid homeostasis, lipid metabolism and immune control, and the varying mechanisms of lymphatic entry and transport are summarized, as well as discussing examples ofymphatic delivery that have enhanced therapeutic utility.
- Type
- article
- Published
- 2015-10-16
- Cited by
- 593
- References
- 297
- Access
- Open access
- OpenAlex
- https://openalex.org/W26471369
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:399682
Keywords
Philosophy
References
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- Glyceride-Mimetic Prodrugs Incorporating Self-Immolative Spacers Promote Lymphatic Transport, Avoid First-Pass Metabolism, and Enhance Oral Bioavailability.
- Lymphatic Transport and Lymphocyte Targeting of a Triglyceride Mimetic Prodrug Is Enhanced in a Large Animal Model: Studies in Greyhound Dogs.
- Enabling Oral SN38-Based Chemotherapy with a Combined Lipophilic Prodrug and Self-Microemulsifying Drug Delivery System.
- Leveraging Physiology for Precision Drug Delivery
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