Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans
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Summary
The findings suggest that the insulin/IGF-I pathway ultimately exerts its effect on lifespan by upregulating a wide variety of genes, including cellular stress-response, antimicrobial and metabolic genes, and by downregulating specific life-shortening genes.
- Type
- article
- Published
- 2003-07-17
- Cited by
- 2,291
- References
- 58
- OpenAlex
- https://openalex.org/W2166146113
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:4424249
Keywords
Caenorhabditis elegans, Biology, Gene, Transcription factor, Microarray analysis techniques
References
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- Transcriptional outputs of the Caenorhabditis elegans forkhead protein DAF‐16
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Cited by
- Multiple roles for UNC-53/NAV2 in cell migration, trafficking and innate immunity in Caenorhabditis elegans
- Genetic and pharmacologic analysis of the mechanisms of selenium toxicity in Caenorhabditis elegans
- Myc/Max/Mad in invertebrates: the evolution of the Max network.
- Akt negatively regulates the in vitro lifespan of human endothelial cells via a p53/p21‐dependent pathway
- Vascular cell senescence and vascular aging.
- Mutations in Chemosensory Cilia Cause Resistance to Paraquat in Nematode Caenorhabditis elegans*
- IGFs and aging: is there a rationale for hormone replacement therapy?
- The TOR pathway interacts with the insulin signaling pathway to regulate C. elegans larval development, metabolism and life span
- Generating phenotypic variation: prospects from “evo‐devo” research on Bicyclus anynana wing patterns
- New Genes Tied to Endocrine, Metabolic, and Dietary Regulation of Lifespan from a Caenorhabditis elegans Genomic RNAi Screen
- Alternate metabolism during the dauer stage of the nematode Caenorhabditis elegans.
- Design and analysis in genetic studies of human ageing and longevity.
- Regulation of Caenorhabditis elegans lifespan by a proteasomal E3 ligase complex
- GRO-alpha: a potential marker for cancer and aging silenced by RNA interference.
- The Mediator Subunit MDT-15 Confers Metabolic Adaptation to Ingested Material
- Higher circulating levels of IGF-1 are associated with longer leukocyte telomere length in healthy subjects.
- Control of intestinal bacterial proliferation in regulation of lifespan in Caenorhabditis elegans
- Dimethyl sulfoxide and dimethyl formamide increase lifespan of C. elegans in liquid.
- DJR-1.2 of Caenorhabditis elegans is induced by DAF-16 in the dauer state.
- TATN-1 Mutations Reveal a Novel Role for Tyrosine as a Metabolic Signal That Influences Developmental Decisions and Longevity in Caenorhabditis elegans
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