Deceptively simple but simply deceptive – Caenorhabditis elegans lifespan studies: Considerations for aging and antioxidant effects
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Summary
This review introduces C. elegans as a model organism, discusses aspects that make it attractive for aging and antioxidant research, and addresses some problems and potential artifacts.
- Type
- review
- Published
- 2009-11-03
- Cited by
- 117
- References
- 140
- Access
- Open access
- OpenAlex
- https://openalex.org/W1971840302
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:29891312
Keywords
Caenorhabditis elegans, Model organism, Organism, Longevity, Biology
References
- Specific interference by ingested dsRNA
- Tocotrienols: constitutional effects in aging and disease.
- Three mutants that extend both mean and maximum life span of the nematode, Caenorhabditis elegans, define the age-1 gene.
- Genetic analysis of life-span in Caenorhabditis elegans.
- The gerontogenes age‐1 and daf‐2 determine metabolic rate potential in aging Caenorhabditis elegans
- The measurement and analysis of age-related changes in Caenorhabditis elegans.
- In vivo spectrofluorimetry reveals endogenous biomarkers that report healthspan and dietary restriction in Caenorhabditis elegans
- Genetic pharmacology: interactions between drugs and gene products in Caenorhabditis elegans.
- Life span of the wild and mutant nematode Caenorhabditis elegans: Effects of Sex, Sterilization, and Temperature
- C. Elegans II
- Oxidative stress and ageing in Caenorhabditis elegans.
- The Nematode Caenorhabditis elegans
- Studies on aging in Nematodes. I. The nematode as a model organism for aging research.
- The daf‐2 gene network for longevity regulates oxidative stress resistance and Mn‐superoxide dismutase gene expression in Caenorhabditis elegans
- Assessing metabolic activity in aging Caenorhabditis elegans: concepts and controversies
- The retardation of aging in mice by dietary restriction: longevity, cancer, immunity and lifetime energy intake.
- Studies on ageing in nematodes III. Electronmicroscopical studies on age-associated cellular damage
- Psoralea corylifolia L. Inhibits Mitochondrial Complex I and Proteasome Activities in SH‐SY5Y Cells
- Calorie restriction limits the generation but not the progression of mitochondrial abnormalities in aging skeletal muscle
- A steroid hormone that extends the lifespan of Caenorhabditis elegans
Cited by
- Medicinal plants and antioxidants: what do we learn from cell culture and Caenorhabditis elegans studies?
- Analysis of aging in Caenorhabditis elegans.
- The antioxidant paradox: less paradoxical now?
- Aumento da resistência ao estresse oxidativo induzido pelo Extrato Hidroalcoólico de Carqueja (Baccharis trimera) no Caenorhabditis elegans: seria através de um mecanismo SKN-1/p38 MAPK e DAF-16 dependente?
- Caenorhabditis elegans: What We Can and Cannot Learn from Aging Worms
- Continuous-flow C. elegans fluorescence expression analysis with real-time image processing through microfluidics.
- Re-evaluating the role of ELT-3 in a GATA transcription factor circuit proposed to guide aging in C. elegans.
- Antioxidants: Molecules, medicines, and myths.
- Endogenous ROS levels in C. elegans under exogenous stress support revision of oxidative stress theory of life-history tradeoffs
- Caenorhabditis elegans Life Span Studies: The Challenge of Maintaining Synchronous Cohorts
- Mitochondrial hormesis links low-dose arsenite exposure to lifespan extension
- Lactobacillus salivarius strain FDB89 induced longevity in Caenorhabditis elegans by dietary restriction
- Free radicals and antioxidants: updating a personal view.
- Knockout of a putative ergothioneine transporter in Caenorhabditis elegans decreases lifespan and increases susceptibility to oxidative damage
- The C. elegans lifespan assay toolkit.
- Assessing Different Mechanisms of Toxicity in Mountaintop Removal/Valley Fill Coal Mining-Affected Watershed Samples Using Caenorhabditis elegans
- Lack of blinding of outcome assessors in animal model experiments implies risk of observer bias.
- Long-term dietary exposure to low concentration of dichloroacetic acid promoted longevity and attenuated cellular and functional declines in aged Drosophila melanogaster
- The invertebrate Caenorhabditis elegans biosynthesizes ascorbate
- Pharmacological Lifespan Extension of Invertebrates
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