Transcriptome-Based Network Analysis Reveals a Spectrum Model of Human Macrophage Activation
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Summary
By integrating murine data from the ImmGen project, this work proposes a refined, activation-independent core signature for human and murine macrophages that serves as a framework for future research into regulation of macrophage activation in health and disease.
- Type
- article
- Published
- 2014-02-20
- Cited by
- 1,947
- References
- 57
- Access
- Open access
- OpenAlex
- https://openalex.org/W2162166699
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:8419776
Keywords
Macrophage polarization, Transcriptome, Macrophage, Biology, Cell biology
References
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Cited by
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- Dealing with Danger in the CNS: The Response of the Immune System to Injury
- Gene expression profiling of the human natural killer cell response to Fc receptor activation: unique enhancement in the presence of interleukin-12
- Functional Immune Anatomy of the Liver—As an Allograft
- Macrophage polarization in nerve injury: do Schwann cells play a role?
- Macrophages in Vascular Inflammation: Origins and Functions
- Insulin-Like Growth Factor 1 Receptor Deficiency in Macrophages Accelerates Atherosclerosis and Induces an Unstable Plaque Phenotype in Apolipoprotein E Deficient Mice
- Full Spectrum of LPS Activation in Alveolar Macrophages of Healthy Volunteers by Whole Transcriptomic Profiling
- Dual polarization of human alveolar macrophages progressively increases with smoking and COPD severity
- Crucial role of Mer tyrosine kinase in the maintenance of SIGN‐R1+ marginal zone macrophages
- The continuum of monocyte phenotypes: Experimental evidence and prognostic utility in assessing cardiovascular risk
- Controlled M1-to-M2 transition of aged macrophages by calcium phosphate coatings
- Transcriptome network analysis identifies protective role of the LXR/SREBP-1c axis in murine pulmonary fibrosis.
- Polarization of Rheumatoid Macrophages by TNF Targeting Through an IL-10/STAT3 Mechanism
- The emerging roles of macrophages in cancer metastasis and response to chemotherapy
- Airway macrophages as the guardians of tissue repair in the lung
- Enabling systems-level analyses of the host response to infectious diseases in bovine and other mammalian species
- α7 nicotinic acetylcholine receptors at the glutamatergic synapse
- Polarisation et rôle des macrophages dans des contextes inflammatoires aigus et chroniques
- The role of macrophages in the innate immune response to Streptococcus pneumoniae and Staphylococcus aureus: mechanisms and contrasts.
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