Dual polarization of human alveolar macrophages progressively increases with smoking and COPD severity
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Summary
In normal lungs alveolar macrophages were mostly non-polarized, but with smoking and COPD severity, M1 and M2 polarization increased significantly and so did the co-expression of M2 and M1 in the same alveolar Macrophage in severe COPD.
- Type
- article
- Published
- 2017-02-23
- Cited by
- 142
- References
- 43
- Access
- Open access
- OpenAlex
- https://openalex.org/W28231829
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:5875607
Keywords
Psychology, Humanities, Philosophy
References
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- &agr;1‐Antitrypsin Polymerizes in Alveolar Macrophages of Smokers With and Without &agr;1‐Antitrypsin Deficiency
- Characterization of the pulmonary and systemic immune response in relation with lung stem cells in patients with COPD
- Impaired Adipogenesis and Dysfunctional Adipose Tissue in Human Hypertrophic Obesity.
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- Oxidative stress and macrophages: driving forces behind exacerbations of asthma and chronic obstructive pulmonary disease?
- Macrophage Biology in the Peripheral Nervous System after Injury
- Rhinovirus-induces progression of lung disease in a mouse model of COPD via IL-33/ST2 signaling axis
- RNA-sequencing across three matched tissues reveals shared and tissue-specific gene expression and pathway signatures of COPD
- NETs promote ALI/ARDS inflammation by regulating alveolar macrophage polarization.
- Molecular Characteristics and Treatment of Endothelial Dysfunction in Patients with COPD: A Review Article
- Inflammaging and Oxidative Stress in Human Diseases: From Molecular Mechanisms to Novel Treatments
- Multi-walled carbon nanotubes activate and shift polarization of pulmonary macrophages and dendritic cells in an in vivo model of chronic obstructive lung disease
- Pulmonary toxicity in rats following inhalation exposure to poorly soluble particles: The issue of impaired clearance and the relevance for human health hazard and risk assessment.
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