Full Spectrum of LPS Activation in Alveolar Macrophages of Healthy Volunteers by Whole Transcriptomic Profiling
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Summary
Results suggest that IRF-7 and predicted downstream target USP18, both elements of a type I interferon gene signature identified by RNA-Seq, may serve to fine-tune early cytokine response by calibrating IL-10 production in human alveolar macrophages.
- Type
- article
- Published
- 2016-07-19
- Cited by
- 34
- References
- 60
- Access
- Open access
- OpenAlex
- https://openalex.org/W27434537
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:18207926
Keywords
Macro, Computer science, Pyrometer, Simple (philosophy), Large format
References
- Bacterial pneumonia. Managing a deadly complication of influenza in older adults with comorbid disease.
- TLR4 mutations are associated with endotoxin hyporesponsiveness in humans
- Aicardi–Goutières syndrome and the type I interferonopathies
- Neutralization of IL-10 increases survival in a murine model of Klebsiella pneumonia.
- CD91: a receptor for heat shock protein gp96
- Human intracellular ISG15 prevents interferon-α/β over-amplification and auto-inflammation
- Cutting Edge: Involvement of the Type I IFN Production and Signaling Pathway in Lipopolysaccharide-Induced IL-10 Production1
- Mycobacterium tuberculosis-Induced CXCR4 and Chemokine Expression Leads to Preferential X4 HIV-1 Replication in Human Macrophages1
- Immunomodulatory functions of type I interferons
- By binding SIRPalpha or calreticulin/CD91, lung collectins act as dual function surveillance molecules to suppress or enhance inflammation.
- Immune-responsive gene 1 protein links metabolism to immunity by catalyzing itaconic acid production
- Expression of CCR5 Is Increased in Human Monocyte-Derived Macrophages and Alveolar Macrophages in the Course of in Vivo and in Vitro Mycobacterium tuberculosis Infection
- Selective inactivation of USP18 isopeptidase activity in vivo enhances ISG15 conjugation and viral resistance
- Life-threatening influenza and impaired interferon amplification in human IRF7 deficiency
- RNA degradation in antiviral immunity and autoimmunity
- Differential gene expression analysis in human monocyte-derived macrophages: impact of cigarette smoke on host defence.
- ST2 is an inhibitor of interleukin 1 receptor and Toll-like receptor 4 signaling and maintains endotoxin tolerance
- CD91-dependent programming of T helper cell responses following Heat Shock Protein immunization
- Transcriptional re-programming of primary macrophages reveals distinct apoptotic and anti-tumoral functions of IRF-3 and IRF-7
- Regulation of type I interferon responses
Cited by
- Identifying breed differences in insulin dynamics, skeletal muscle and adipose tissue histology and gene expression
- Human Lung Mononuclear Phagocytes in Health and Disease
- RNA-sequencing Identifies Novel Pathways in Sarcoidosis Monocytes
- Structure–Function Relationships Underlying the Capacity of Bordetella Adenylate Cyclase Toxin to Disarm Host Phagocytes
- Decidual T cells exhibit a highly differentiated phenotype and demonstrate potential fetal-specificity and a strong transcriptional response to interferon
- Respiratory Mononuclear Phagocytes in Human Influenza A Virus Infection: Their Role in Immune Protection and As Targets of the Virus
- ADGRE1 (EMR1, F4/80) Is a Rapidly-Evolving Gene Expressed in Mammalian Monocyte-Macrophages
- Iron Homeostasis in the Lungs—A Balance between Health and Disease
- A genome-wide association study of resistance to Pseudomonas plecoglossicida infection in the large yellow croaker (Larimichthys crocea)
- Switch of NAD Salvage to de novo Biosynthesis Sustains SIRT1-RelB-Dependent Inflammatory Tolerance
- The role of deubiquitinating enzymes in gastric cancer
- FOXO3a is stabilized by USP18-mediated de-ISGylation and inhibits TGF-β1-induced fibronectin expression
- Single cell rna sequencing identifies an early monocyte gene signature in acute respiratory distress syndrome.
- Changes in H3K27ac at Gene Regulatory Regions in Porcine Alveolar Macrophages Following LPS or PolyIC Exposure
- Stressed erythrophagocytosis induces immunosuppression during sepsis through heme-mediated STAT1 dysregulation.
- How Macrophages Become Transcriptionally Dysregulated: A Hidden Impact of Antitumor Therapy
- Liver macrophages and inflammation in physiology and physiopathology of non‐alcoholic fatty liver disease
- Effects of equine SALSA on neutrophil phagocytosis and macrophage cytokine production
- Akkaraman ve Romanov Kuzularının Alveolar Makrofajlarında Lipopolisakkarit ve Lipoteikoik Asite Yanıtta İmmün İlişkili Genlerin Ekspresyon Profilinin Araştırılması
- Mechanoimmunology: Are inflammatory epigenetic states of macrophages tuned by biophysical factors?
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