Integrated Regulation of Toll-like Receptor Responses by Notch and Interferon-γ Pathways
Explore this paper's citation graph
Summary
It is found that Notch and TLR pathways cooperated to activate canonical Notch target genes, including transcriptional repressors Hes1 and Hey1, and to increase production of canonical TLR-induced cytokines TNF, IL-6 and IL-12.
- Type
- article
- Published
- 2008-10-30
- Cited by
- 269
- References
- 61
- Access
- Open access
- OpenAlex
- https://openalex.org/W2006828798
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:7996292
Keywords
HES1, Notch signaling pathway, Biology, Cell biology, Transcription factor
References
- Interferon- : an overview of signals, mechanisms and functions
- Notch1 and IL-7 Receptor Interplay Maintains Proliferation of Human Thymic Progenitors while Suppressing Non-T Cell Fates1
- Notch Signaling Augments T Cell Responsiveness by Enhancing CD25 Expression 1
- Notch-1 Up-Regulation and Signaling following Macrophage Activation Modulates Gene Expression Patterns Known to Affect Antigen-Presenting Capacity and Cytotoxic Activity1
- Notch 1 signaling regulates peripheral T cell activation.
- EBNA2 and Activated Notch Induce Expression of BATF
- Sensitization of IFN-γ Jak-STAT signaling during macrophage activation
- Notch signalling: a simple pathway becomes complex
- The negative regulation of Toll‐like receptor and associated pathways
- Histone H3 phosphorylation by IKK-α is critical for cytokine-induced gene expression
- Notch signalling in vertebrate neural development
- Differential regulation of interleukin 1 receptor and Toll-like receptor signaling by MEKK3
- Notch signaling is activated by TLR stimulation and regulates macrophage functions
- The Notch ligand, Delta-1, inhibits the differentiation of monocytes into macrophages but permits their differentiation into dendritic cells.
- Regulation of osteoclast development by Notch signaling directed to osteoclast precursors and through stromal cells.
- Comparative analysis of the human and mouse Hey1 promoter: Hey genes are new Notch target genes.
- Negative regulation of Toll-like receptor-mediated immune responses
- Oscillatory Expression of the bHLH Factor Hes1 Regulated by a Negative Feedback Loop
- Notch–RBP-J signaling is involved in cell fate determination of marginal zone B cells
- Direct regulation of Gata3 expression determines the T helper differentiation potential of Notch.
Cited by
- Inhibition of Notch Signaling Protects Mouse Lung Against Zymosan-Induced Injury
- Dengue virus up‐regulates expression of notch ligands Dll1 and Dll4 through interferon‐β signalling pathway
- Interferon gamma in autoimmunity: A complicated player on a complex stage.
- Endothelial Jag1-RBPJ signalling promotes inflammatory leucocyte recruitment and atherosclerosis.
- CpG in Combination with an Inhibitor of Notch Signaling Suppresses Formalin-Inactivated Respiratory Syncytial Virus-Enhanced Airway Hyperresponsiveness and Inflammation by Inhibiting Th17 Memory Responses and Promoting Tissue-Resident Memory Cells in Lungs
- Acetylation-Dependent Regulation of Notch Signaling in Macrophages by SIRT1 Affects Sepsis Development
- Macrophage proinflammatory activation and deactivation: a question of balance.
- Non-instructional roles for Notch signaling in T cell development
- Functional analysis of zebrafish innate immune responses to inflammatory signals
- Correlation of Notch1/Hes1 Genes Expression Levels in Egyptian Paediatric Patients with Newly Diagnosed and Persistent Primary Immune(Idiopathic) Thrombocytopenic Purpura
- A Novel Role of Numb as A Regulator of Pro-inflammatory Cytokine Production in Macrophages in Response to Toll-like Receptor 4
- DLK1 is a novel inflammatory inhibitor which interferes with NOTCH1 signaling in TLR‐activated murine macrophages
- Interferon-γ regulates cellular metabolism and mRNA translation to potentiate macrophage activation
- Nitric Oxide Is Involved in Mycobacterium bovis Bacillus Calmette-Guérin–Activated Jagged1 and Notch1 Signaling
- Impact of Notch1 Deletion in Macrophages on Pro-inflammatory Cytokine Production and the Outcome of Experimental Autoimmune Encephalomyelitis
- BloodSpot: a database of gene expression profiles and transcriptional programs for healthy and malignant haematopoiesis
- TLR7 and TLR8 expression increases tumor cell proliferation and promotes chemoresistance in human pancreatic cancer
- Modulation of macrophage activation and programming in immunity
- Notch signaling regulates expression of Mcl-1 and apoptosis in PPD-treated macrophages
- Notch1 upregulates LPS‐induced macrophage activation by increasing NF‐κB activity
Related papers
- Regulation of NOTCH Signaling by Reciprocal Inhibition of HES1 and Deltex 1 and its Role in Osteosarcoma Invasiveness
- Notch signalling is off and is uncoupled from HES1 expression in Ewing's sarcoma
- [P2.15]: Oscillations in notch signaling regulate maintenance of neural progenitors
- Neural fate decisions mediated by notch-delta signaling
- Multiple roles of Notch signaling in the regulation of epidermal development.
- Dynamic Notch signaling in neural progenitor cells and a revised view of lateral inhibition
- Down-regulated expression of Notch signaling molecules in human endometrial cancer
- Abstract 1936: Notch signaling is switched off and displays properties of a tumor suppressor in Ewing's sarcoma
- Involvement of Notch signaling in the osteogenic differentiation of human mesenchymal stem cells stimulated by pulsed electromagnetic fields
- The Notch Inhibitors Isolated from Nerium indicum.