Integrated Regulation of Toll-like Receptor Responses by Notch and Interferon-γ Pathways

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Summary

It is found that Notch and TLR pathways cooperated to activate canonical Notch target genes, including transcriptional repressors Hes1 and Hey1, and to increase production of canonical TLR-induced cytokines TNF, IL-6 and IL-12.

Type
article
Published
2008-10-30
Cited by
269
References
61
Access
Open access

Keywords

HES1, Notch signaling pathway, Biology, Cell biology, Transcription factor

References

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