Natural killer cell stimulatory factor (interleukin 12 [IL-12]) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing Th cells
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Summary
IL-12 and CD16+ cells appear to have inhibitory effects on the development of IL-4-producing cells and to play an inductive role in promoting Th1-like responses.
- Type
- article
- Published
- 1993-04-01
- Cited by
- 1,778
- References
- 33
- Access
- Open access
- OpenAlex
- https://openalex.org/W2161485037
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:7437050
Keywords
Biology, T cell, Immune system, Cytokine, Molecular biology
References
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- Selection of a human T helper type 1-like T cell subset by mycobacteria
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- Reciprocal regulatory effects of IFN-gamma and IL-4 on the in vitro development of human Th1 and Th2 clones.
- Heterogeneity of cytokine secretion patterns and functions of helper T cells.
- Biology of Natural Killer Cells
- IFN-gamma modulates the early development of Th1 and Th2 responses in a murine model of cutaneous leishmaniasis.
- Mutant EL-4 thymoma cells polyclonally activate murine and human B cells via direct cell interaction.
- Heterogeneity of mouse helper T cells. Evidence from bulk cultures and limiting dilution cloning for precursors of Th1 and Th2 cells.
- Profiles of lymphokine activities and helper function for IgE in human T cell clones
- Coexpression of two distinct genes is required to generate secreted bioactive cytotoxic lymphocyte maturation factor.
- Allergen- and bacterial antigen-specific T-cell clones established from atopic donors show a different profile of cytokine production.
- Novel interleukin 2 (IL-2) receptor appears to mediate IL-2-induced activation of natural killer cells.
- Limiting dilution assays for the determination of immunocompetent cell frequencies. III. Validity tests for the single-hit Poisson model.
- Purified protein derivative of Mycobacterium tuberculosis and excretory-secretory antigen(s) of Toxocara canis expand in vitro human T cells with stable and opposite (type 1 T helper or type 2 T helper) profile of cytokine production.
- Natural killer (NK) cell stimulatory factor increases the cytotoxic activity of NK cells from both healthy donors and human immunodeficiency virus-infected patients
- Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes
- Response of resting human peripheral blood natural killer cells to interleukin 2
- Cloning of cDNA for natural killer cell stimulatory factor, a heterodimeric cytokine with multiple biologic effects on T and natural killer cells.
Cited by
- Development of th 1- or th 2-dominated immune responses: what about the polarizing signals?
- Phenotypic and functional characteristics of in vivo-induced interleukin-12-activated killer cells.
- Interleukin 12 Upregulates the Release of Vascular Permeability Factor by Peripheral Blood Mononuclear Cells from Patients with Lipoid Nephrosis
- In vivo expression of cytokine receptor mRNA in atopic dermatitis.
- The Th1/Th2 paradigm and allergic disorders.
- Early IL‐12 p70, but not p40, production by splenic macrophages correlates with host resistance to blood‐stage Plasmodium chabaudi AS malaria
- Modulation of IL-10, IL-12, and IFN-gamma in the epidermis of hairless mice by UVA (320-400 nm) and UVB (280-320 nm) radiation.
- Induction of histidine decarboxylase, the histamine-forming enzyme, in mice by interleukin-12.
- Paradoxical effects of IL-12 in leishmaniasis in the presence and absence of vaccinating antigen.
- IL-12-induced production of IL-10 and interferon-gamma by mononuclear cells in lung cancer-associated malignant pleural effusions.
- Interleukin-12 p40 gene (IL12B) 3'-untranslated region polymorphism is associated with susceptibility to atopic dermatitis and psoriasis vulgaris.
- Enhancement of reactive oxygen species production from canine blood leukocytes by human recombinant interleukin-12.
- The immunogenic peptide for Th1 development.
- Interleukin‐4‐expressing plasmid DNA inhibits reovirus type‐2‐triggered autoimmune insulitis in DBA/1 J suckling mice
- Disruption of MAP kinase activation and nuclear factor binding to the IL‐12 p40 promoter in HIV‐infected myeloid cells
- T lymphocytes play a role in neuropathic pain following peripheral nerve injury in rats.
- Imaging analysis of STAT1 and NF-kappaB translocation in dendritic cells at the single cell level.
- Toxoplasma gondii Antigens GRA1 (p24) and SAG1 (p30): A Comparison of Their Stimulatory Influence on T-Cell Activation and Cytokine Expression in in vitro Cultures
- Preferential production of the IL‐12(p40)/IL‐23(p19) heterodimer by dendritic cells from human newborns
- A deficient TLR2 signaling promotes airway mucin production in Mycoplasma pneumoniae-infected allergic mice.
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