Profiles of lymphokine activities and helper function for IgE in human T cell clones
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Summary
Higher proportions of IL4‐producing clones were found among CD4+clones from tonsils and spleens than from peripheral blood and lymph nodes, whereas only a minority of CD8+ clones from all lymphoid tissues were found to produce IL4.
- Type
- article
- Published
- 1988-07-01
- Cited by
- 207
- References
- 13
- OpenAlex
- https://openalex.org/W1972831560
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:27054718
Keywords
Lymphokine, Interleukin 4, Biology, CD8, T helper cell
References
- In vitro production of IgE by human peripheral blood mononuclear cells. III. Demonstration of a circulating IgE-bearing cell involved in the spontaneous IgE biosynthesis.
- Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins.
- Activation through CD3 molecule leads a number of human T cell clones to induce IgE synthesis in vitro by B cells from allergic and nonallergic individuals.
- Suppression of in vivo polyclonal IgE responses by monoclonal antibody to the lymphokine B-cell stimulatory factor 1.
- Interferon-gamma and B cell stimulatory factor-1 reciprocally regulate Ig isotype production.
- Effect of in vitro irradiation and cell cycle-inhibitory drugs on the spontaneous human IgE synthesis in vitro.
- Abnormalities of in vitro immunoglobulin synthesis by peripheral blood lymphocytes from untreated patients with Hodgkin's disease.
- Isolation and characterization of a human interleukin cDNA clone, homologous to mouse B-cell stimulatory factor 1, that expresses B-cell- and T-cell-stimulating activities.
- Direct demonstration of the clonogenic potential of every human peripheral blood T cell. Clonal analysis of HLA-DR expression and cytolytic activity
- Heterogeneity of helper/inducer T lymphocytes. I. Lymphokine production and lymphokine responsiveness
- Human T cell clones can induce in vitro IgE synthesis in normal B cells regardless of alloantigen recognition or specificity for peculiar antigens
- Surface immunoglobulins are involved in the interaction of protein A with human B cells and in the triggering of B cell proliferation induced by protein A-containing Staphylococcus aureus.
Cited by
- Immune regulation and haemopoiesis.
- Analysis of apoptosis and a Th1/Th2 phenotype in HIV-infected patients.
- Cell-mediated immune system regulation in periodontal diseases.
- Highly heterogeneous Phl p 5-specific T cells from patients with allergic rhinitis differentially recognize recombinant Phl p 5 isoallergens.
- TH1-TH2 cells in allergic responses: at the limits of a concept.
- Idiotype-reactive T-cell subsets and tumor load in monoclonal gammopathies.
- Role of T cells in the pathogenesis of Hodgkin's disease.
- Host—Pathogen Interactions in the Immunopathogenesis of Lyme Disease
- Non-instructional roles for Notch signaling in T cell development
- T lymphocyte-derived colony-stimulating factors.
- IL-10 is produced by subsets of human CD4+ T cell clones and peripheral blood T cells.
- Establishment and functional characterization of human herpesvirus 6-specific CD4+ human T-cell clones
- Single Cell Analysis Reveals That IL-4 Receptor/Stat6 Signaling Is Not Required for the In Vivo or In Vitro Development of CD4+ Lymphocytes with a Th2 Cytokine Profile
- Role of T cells in immunity to the intracellular pathogen, Leishmania major.
- Heterogeneity of cytokine secretion patterns and functions of helper T cells.
- Single-Cytokine-Producing CD4 Memory Cells Predominate in Type 1 and Type 2 Immunity1
- Lymphokine secretion and cytotoxic activity of human CD4+ T-cell clones against Bordetella pertussis
- Mucosal mast cell responses are not required for protection against infection with the murine nematode parasite Trichuris muris
- Functional diversity of T lymphocytes due to secretion of different cytokine patterns
- Effects of adjuvants on the immune response to allergens in a murine model of allergen inhalation: cholera toxin induces a Th1‐like response to Bet v 1, the major birch pollen allergen
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