Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages
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Summary
Results identify microglia as an ontogenically distinct population in the mononuclear phagocyte system and have implications for the use of embryonically derived microglial progenitors for the treatment of various brain disorders.
- Type
- article
- Published
- 2010-10-21
- Cited by
- 4,802
- References
- 33
- Access
- Open access
- OpenAlex
- https://openalex.org/W2148898943
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:37501756
Keywords
Microglia, Mononuclear phagocyte system, Biology, Progenitor cell, Macrophage
References
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Cited by
- Etude du rôle des sous-populations monocytaires dans l'obésité et l'insulinorésistance
- [Microglia arise from extra-embryonic yolk sac primitive progenitors].
- Selective localization of bone marrow-derived ramified cells in the brain adjacent to the attachments of choroid plexus.
- Interferon γ-dependent migration of microglial cells in the retina after systemic cytomegalovirus infection.
- Ionic Transporter Activity in Astrocytes, Microglia, and Oligodendrocytes During Brain Ischemia
- The brain’s best friend: microglial neurotoxicity revisited
- From proliferation to proliferation: monocyte lineage comes full circle
- Involvement of monocytes/macrophages as key factors in the development and progression of cardiovascular diseases.
- Neonatal Peripheral Immune Challenge Activates Microglia and Inhibits Neurogenesis in the Developing Murine Hippocampus
- Interkeukin-34, a cytokine crucial for the differentiation and maintenance of tissue resident macrophages and Langerhans cells
- Innate immune viral recognition: relevance to CNS infections.
- Modulation of Atherosclerotic Lesions by Circulating Cells : The Translational Spectrum
- Ontogeny of Myeloid Cells
- Monocyte fate in atherosclerosis.
- The choreography of neuroinflammation in Huntington’s disease
- Microglia are crucial regulators of neuro-immunity during central nervous system tuberculosis
- Dealing with Danger in the CNS: The Response of the Immune System to Injury
- MicroRNA-Let-7a regulates the function of microglia in inflammation.
- Sex differences in neurodevelopmental and neurodegenerative disorders: Focus on microglial function and neuroinflammation during development
- Microglia–blood vessel interactions: a double-edged sword in brain pathologies
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