Targeted inactivation of the sodium‐calcium exchanger (Ncx1) results in the lack of a heartbeat and abnormal myofibrillar organization
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Summary
It is demonstrated that Ncx‐1 is a Ca2+‐ gene that is essential for normal cardiomyocyte development and function and may serve as an animal model for functionally related human congenital heart defects.
- Type
- article
- Published
- 2001-05-01
- Cited by
- 255
- References
- 35
- OpenAlex
- https://openalex.org/W2054799212
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:30168492
Keywords
Heartbeat, Calcium, Myofibril, Sodium-calcium exchanger, Sodium
References
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- Contractile activity modulates actin synthesis and turnover in cultured neonatal rat heart cells.
- What determines the initiation of the heartbeat?
- Myogenic and morphogenetic defects in the heart tubes of murine embryos lacking the homeo box gene Nkx2-5.
- Abnormal skeletogenesis occurs coincident with increased apoptosis in the Splotch (Sp2H) mutant: Putative roles for Pax3 and PDGFRα in rib patterning
- Na(+)-Ca(2+) exchange in failing myocardium: friend or foe?
Cited by
- The sodium/calcium exchanger family—SLC8
- Topics on the Na+/Ca2+ exchanger: involvement of Na+/Ca2+ exchanger in the vasodilator-induced vasorelaxation.
- Stem cells: The stress of forming blood cells
- Modern concepts concerning the origin of the heartbeat.
- Physiology of epithelial Ca2+ and Mg2+ transport.
- Ontogeny and Phylogeny of the Vertebrate Heart
- Determinants of Embryonic Hematopoietic Stem Cell Emergence and Maturation
- Investigating Hemodynamics of the Developing Embryonic Heart using Optical Coherence Tomography
- The effect on rat embryonic heart rate of Na+, K+, and Ca2+ channel blockers, and the human teratogen phenytoin, changes with gestational age.
- Genetically modified mice as a strategy to unravel the role played by the Na(+)/Ca (2+) exchanger in brain ischemia and in spatial learning and memory deficits.
- Hematopoietic Stem Cell Development and Transcriptional Regulation
- Inositol‐1,4,5‐trisphosphate‐mediated spontaneous activity in mouse embryonic stem cell‐derived cardiomyocytes
- Calcium homeostasis in human placenta: role of calcium-handling proteins.
- Neural crest defects in ephrin-B2 mutant mice are non-autonomous and originate from defects in the vasculature
- A functional characterisation of the dimerisation motif in fibronectin, in vivo and in vitro
- Ca2+‐activated K+ current is essential for maintaining excitability and gene transcription in early embryonic cardiomyocytes
- Persistent Noggin arrests cardiomyocyte morphogenesis and results in early in utero lethality
- Connecting Teratogen-Induced Congenital Heart Defects to Neural Crest Cells and Their Effect on Cardiac Function
- Transcription factor ISL1 is essential for pacemaker development and function.
- The ryanodine receptor modulates the spontaneous beating rate of cardiomyocytes during development
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