Effectiveness of Donor Natural Killer Cell Alloreactivity in Mismatched Hematopoietic Transplants
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Summary
It is shown that donor-versus-recipient natural killer (NK)–cell alloreactivity could eliminate leukemia relapse and graft rejection and protect patients against GVHD in human transplants and in mice, the pretransplant infusion of alloreactive NK cells obviated the need for high-intensity conditioning and reduced GV HD.
- Type
- article
- Published
- 2002-03-15
- Cited by
- 3,458
- References
- 34
- OpenAlex
- https://openalex.org/W2147068163
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:33070781
Keywords
Immunology, Graft-versus-host disease, Leukemia, Haematopoiesis, Hematopoietic cell
References
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- Transplants across human leukocyte antigen barriers.
- Regulation of hematopoiesis in vitro by alloreactive natural killer cell clones
- Prevention of graft versus host disease by inactivation of host antigen-presenting cells.
- Megadose of T cell-depleted bone marrow overcomes MHC barriers in sublethally irradiated mice
- Killer cell receptors: keeping pace with MHC class I evolution
- Selective rejection of H–2-deficient lymphoma variants suggests alternative immune defence strategy
- Involvement of HLA class I alleles in natural killer (NK) cell-specific functions: expression of HLA-Cw3 confers selective protection from lysis by alloreactive NK clones displaying a defined specificity (specificity 2)
- Evidence of a natural killer (NK) cell repertoire for (allo) antigen recognition: definition of five distinct NK-determined allospecificities in humans
- Stimulation of mature unprimed CD8+ T cells by semiprofessional antigen- presenting cells in vivo
- NK cell receptors.
- Successful engraftment of T-cell-depleted haploidentical "three-loci" incompatible transplants in leukemia patients by addition of recombinant human granulocyte colony-stimulating factor-mobilized peripheral blood progenitor cells to bone marrow inoculum.
- Treatment of high-risk acute leukemia with T-cell-depleted stem cells from related donors with one fully mismatched HLA haplotype.
- Natural killer cells, HLA class I molecules, and marrow transplantation.
- Blood.
- Immunity
Cited by
- Complications de l'immunothérapie par transfusion de lymphocytes de donneur après greffe de cellules souches hématopoïétiques
- Development of a sample bank and clinical database for the retrospective analysis of unrelated bone marrow transplants : a pilot study of 138 transplants using RSCA for high resolution HLA matching
- Functional expression and release of ligands for the activating immunoreceptor NKG2D in leukemia.
- Altered conjugate formation and altered apoptosis of multidrug‐resistant human leukemia cell line affects susceptibility to killing by activated natural killer (NK) cells
- Clinical responses following nonmyeloablative allogeneic stem cell transplantation for renal cell carcinoma are associated with expansion of CD8+ IFN-γ-producing T cells
- Nonmyeloablative allogeneic immunotherapy for solid tumors.
- Cellular immunotherapy and cancer.
- Immune therapy of chronic myelogenous leukemia.
- Treatment of severe autoimmune disease by stem-cell transplantation
- Control of Metastasized Pancreatic Carcinomas in SCID/Beige Mice with Human IL-2/TKD-Activated NK Cells1
- Induction of tumor immunity following allogeneic stem cell transplantation.
- Innate immune recognition and suppression of tumors.
- The effect of KIR ligand incompatibility on the outcome of unrelated donor transplantation: a report from the center for international blood and marrow transplant research, the European blood and marrow transplant registry, and the Dutch registry.
- The tryptophan catabolite L-kynurenine inhibits the surface expression of NKp46- and NKG2D-activating receptors and regulates NK-cell function.
- Alternative donor transplantation in acute myeloid leukemia: which source and when?
- Allogeneic Intrabone Marrow‐Bone Marrow Transplantation plus Donor Lymphocyte Infusion Suppresses Growth of Colon Cancer Cells Implanted in Skin and Liver of Rats
- Antitumor Effect of Large Doses IL-2-Activated HLA Haploidentical Peripheral Blood Stem Cells on Refractory Metastatic Solid Tumor Treatment
- Hierarchy of the Human Natural Killer Cell Response Is Determined by Class and Quantity of Inhibitory Receptors for Self-HLA-B and HLA-C Ligands1
- Biological advances in acute graft-versus-host disease after allogeneic hematopoietic stem cell transplantation.
- Does T-cell depletion have a future in allogeneic stem cell transplantation?
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