Stimulation of mature unprimed CD8+ T cells by semiprofessional antigen- presenting cells in vivo
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Summary
These cells were nonimmunogenic for most host- reactive CD8+ cells but were capable of stimulating a small subset of high-affinity T cells, and the possible relevance of the data to the prolonged immunogenicity of vascularized allografts in humans is discussed.
- Type
- article
- Published
- 1992-11-01
- Cited by
- 70
- References
- 41
- Access
- Open access
- OpenAlex
- https://openalex.org/W2148167040
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:15481813
Keywords
CD40, Cytotoxic T cell, Biology, Antigen-presenting cell, Antigen
References
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- Antigen presentation by interferon-gamma-treated endothelial cells and fibroblasts: differential ability to function as antigen-presenting cells despite comparable Ia expression.
- Monoclonal antibodies to Pgp-1/CD44 block lympho-hemopoiesis in long- term bone marrow cultures
- Characterization of murine thymocytes with CDS-associated T-cell receptor structures
- Prevention of rejection of murine islet allografts by pretreatment with anti-dendritic cell antibody.
- T cell contact with Ia antigens on nonhemopoietic cells in vivo can lead to immunity rather than tolerance
- Capacity of small B cell‐enriched populations to stimulate mixed lymphocyte reactions: marked differences between irradiated vs. mitomycin C‐treated stimulators
- Strong T cell tolerance in parent----F1 bone marrow chimeras prepared with supralethal irradiation. Evidence for clonal deletion and anergy
- Expression of interleukin-2 receptors as a differentiation marker on intrathymic stem cells
- Identification and initial characterization of a rat monoclonal antibody reactive with the murine interleukin 2 receptor-ligand complex.
- Characterization of the Murine Antigenic Determinant, Designated L3T4a, Recognized by Monoclonal Antibody GK 1.5: Expression of L3T4a by Functional T Cell Clones Appears to Correlate Primarily with Class II MHC Antigen‐Reactivity
- Mouse leukemia: therapy with monoclonal antibodies against a thymus differentiation antigen.
- Peptide-dependent recognition of H–2Kb by alloreactive cytotoxic T lymphocytes
- Migration of dendritic leukocytes from cardiac allografts into host spleens. A novel pathway for initiation of rejection
- The Endothelial Cell as a Regulator of T‐Cell Function
Cited by
- Lineage Extrinsic and Intrinsic Control of Immunoregulatory Cell Numbers by SHIP
- Rat stem cells developing in irradiated SCID mice fail to become tolerized and cause lethal graft-versus-host disease.
- Critical Role of TLR9 in Acute Graft-versus-Host Disease1
- Discovery and Development of Small Molecule SHIP Phosphatase Modulators
- Natural killer cells in cancer : studies on migration and cytotoxicity
- Antigen Presentation by Nonhemopoietic Cells Amplifies Clonal Expansion of Effector CD8 T Cells in a Pathogen-Specific Manner1
- The Role of Tumor Suppressors, SHIP and Rb, in Immune Suppressive Cells
- Mechanisms of Graft-vs.-Leukemia against a Novel Murine Model of Chronic Myelogenous Leukemia
- Antigen-presenting cell engineering. The molecular toolbox.
- Alloreactive Memory T Cells Are Responsible for the Persistence of Graft-versus-Host Disease1
- Embryonic Thymic Epithelium Naturally Devoid of APCs Is Acutely Rejected in the Absence of Indirect Recognition1
- Donor T-cell alloreactivity against host thymic epithelium limits T-cell development after bone marrow transplantation.
- Intrathymic and Extrathymic Tolerance in Bone Marrow Chimeras
- Turnover of naive- and memory-phenotype T cells
- Thymic selection by a single MHC/peptide ligand produces a semidiverse repertoire of CD4+ T cells.
- KIR-ligand mismatch in allogeneic hematopoietic stem cell transplantation.
- Increased Infection-Related Mortality in KIR-Ligand–Mismatched Unrelated Allogeneic Hematopoietic Stem-Cell Transplantation
- Antigen receptor engagement delivers a stop signal to migrating T lymphocytes.
- A role for SHIP in stem cell biology and transplantation.
- Upregulation of surface markers on dying thymocytes
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