Integrins in cancer: biological implications and therapeutic opportunities
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Summary
Clinical developments emphasize the need to identify how integrin antagonists influence the tumour and its microenvironment.
- Type
- review
- Published
- 2010-01-01
- Cited by
- 3,646
- References
- 203
- OpenAlex
- https://openalex.org/W2147000598
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:3165905
Keywords
Integrin, Cancer research, Metastasis, Cell adhesion, Receptor
References
- CXCR4 chemokine receptor and integrin signaling co-operate in mediating adhesion and chemoresistance in small cell lung cancer (SCLC) cells
- Drug evaluation: Volociximab, an angiogenesis-inhibiting chimeric monoclonal antibody.
- A Signaling Pathway from the α5β1 and αvβ3 Integrins That Elevatesbcl-2 Transcription*
- High expression level of alpha 6 integrin in human breast carcinoma is correlated with reduced survival.
- Selective recognition of cyclic RGD peptides of NMR defined conformation by alpha IIb beta 3, alpha V beta 3, and alpha 5 beta 1 integrins.
- Integrin distribution in malignant melanoma: association of the beta 3 subunit with tumor progression.
- Interaction of integrins alpha v beta 3 and glycoprotein IIb-IIIa with fibrinogen. Differential peptide recognition accounts for distinct binding sites.
- Tumor-specific expression of αvβ3 integrin promotes spontaneous metastasis of breast cancer to bone
- Superactivation of integrin alphavbeta3 by low antagonist concentrations.
- Integrin receptor imaging of breast cancer: a proof-of-concept study to evaluate 99mTc-NC100692.
- The integrin alphavbeta3 is a receptor for the latency-associated peptides of transforming growth factors beta1 and beta3.
- Accelerated Metastasis after Short-Term Treatment with a Potent Inhibitor of Tumor Angiogenesis
- Integrin-regulated FAK-Src signaling in normal and cancer cells.
- Transforming growth factor beta induces clustering of HER2 and integrins by activating Src-focal adhesion kinase and receptor association to the cytoskeleton.
- Glioblastoma expression of vitronectin and the alpha v beta 3 integrin. Adhesion mechanism for transformed glial cells.
- Down-regulation of integrin alpha2 surface expression by mutant epidermal growth factor receptor (EGFRvIII) induces aberrant cell spreading and focal adhesion formation.
- Intercavitary Placement of Lymphokine-Activated Killer (LAK) Cells After Resection of Primary Glioblastoma: A Planned Interim Analysis
- Cell adhesion protein receptors as targets for transforming growth factor-beta action.
- Re-expression of the alpha 2 beta 1 integrin abrogates the malignant phenotype of breast carcinoma cells.
- alpha vbeta 6 Integrin promotes the invasion of morphoeic basal cell carcinoma through stromal modulation.
Cited by
- Activation of fibroblasts in cancer stroma.
- Integrin signalling adaptors: not only figurants in the cancer story
- Molecular imaging of integrin αvβ6 expression in living subjects.
- DeltaNp63alpha-Mediated Induction of Epidermal Growth Factor Receptor Promotes Pancreatic Cancer Cell Growth and Chemoresistance
- Subcutaneous passage increases cell aggressiveness in a xenograft model of diffuse large B cell lymphoma
- N-cadherin expression level as a critical indicator of invasion in non-epithelial tumors
- Targeting receptor-mediated endocytotic pathways with nanoparticles: rationale and advances
- Overexpression of integrin-β1 in leiomyoma promotes cell spreading and proliferation.
- Cyclic RGD peptide incorporation on phage major coat proteins for improved internalization by HeLa cells.
- Temperature-triggered tumor-specific delivery of anticancer agents by cRGD-conjugated thermosensitive liposomes.
- The Aspect Ratio of Nanoparticle Assemblies and the Spatial Arrangement of Ligands can be Optimized to Enhance the Targeting of Cancer Cells
- Single cell tracking assay reveals an opposite effect of selective small non-peptidic α5β1 or αvβ3/β5 integrin antagonists in U87MG glioma cells.
- Microenvironmental interactions in chronic lymphocytic leukemia: the master role of CD49d.
- Characterization and identification of the integrin family in silkworm, Bombyx mori.
- Chromogranin A: a paradoxical player in angiogenesis and vascular biology
- Cancer cells remodel themselves and vasculature to overcome the endothelial barrier
- Glycogen Synthase Kinase 3β Sustains Invasion of Glioblastoma via the Focal Adhesion Kinase, Rac1, and c-Jun N-Terminal Kinase-Mediated Pathway
- iRGD-conjugated DSPE-PEG2000 nanomicelles for targeted delivery of salinomycin for treatment of both liver cancer cells and cancer stem cells.
- From sewer to saviour — targeting the lymphatic system to promote drug exposure and activity
- Evaluation of MicroRNAs Regulating Anoikis Pathways and Its Therapeutic Potential
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