Fibronectin-bound α5β1 integrins sense load and signal to reinforce adhesion in less than a second.
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Summary
During adhesion initiation, fibroblasts respond to mechanical load by strengthening integrin-mediated adhesion to fibronectin (FN) in a biphasic manner, mediated by α5β1 integrins, which form catch bonds with FN and signal to FN-binding integrin to reinforce cell adhesion much before visible adhesion clusters are formed.
- Type
- article
- Published
- 2017-11-06
- Cited by
- 138
- References
- 50
- OpenAlex
- https://openalex.org/W2767469072
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:19456852
Keywords
Fibronectin, Integrin, Adhesion, Sense (electronics), Fibronectins
References
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Cited by
- The Kank family proteins in adhesion dynamics.
- Instant integrin mechanosensing
- Mechanosensing at integrin-mediated cell-matrix adhesions: from molecular to integrated mechanisms.
- Cdc42-dependent modulation of rigidity sensing and cell spreading in tumor repopulating cells
- Mechanical Polyprotein Assembly Using Sfp and Sortase‐Mediated Domain Oligomerization for Single‐Molecule Studies
- A Photoactivatable α5β1‐Specific Integrin Ligand
- Basement membrane extract attenuates the more malignant gene expression profile accentuated by fibronectin in prostate cancer cells
- Cellular Mechanotransduction: From Tension to Function
- Signaling mechanisms of myofibroblastic activation: outside-in and inside-out
- Bone Physiology as Inspiration for Tissue Regenerative Therapies
- Unforgettable force – crosstalk and memory of mechanosensitive structures
- Integrin activation by talin, kindlin and mechanical forces
- Regulation of osteoblast functions on titanium surfaces with different micro/nanotopographies and compositions
- Advances in atomic force microscopy for single-cell analysis
- Universal Kinetics of the Onset of Cell Spreading on Substrates of Different Stiffness
- Nano-scale design of cardiovascular biomaterials
- Tensile and compressive force regulation on cell mechanosensing
- Imaging: Gear up for mechano-immunology.
- Synergistic Effect of Matrix Stiffness and Inflammatory Factors on Osteogenic Differentiation of MSC.
- Integrins as biomechanical sensors of the microenvironment
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