Deacetylase inhibition promotes the generation and function of regulatory T cells
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Summary
Administration of an HDAC inhibitor (HDACi) in vivo increased Foxp3 gene expression, as well as the production and suppressive function of regulatory T cells (Treg cells), and HDAC9 proved particularly important in regulatingFoxp3-dependent suppression.
- Type
- article
- Published
- 2007-11-01
- Cited by
- 947
- References
- 50
- OpenAlex
- https://openalex.org/W2141615498
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:1605586
Keywords
FOXP3, Acetylation, Cell biology, Chromatin, Cancer research
References
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- Quantifying the Frequency of Alloreactive T Cells In Vivo: New Answers to an Old Question1
- The histone deacetylase inhibitor Trichostatin A modulates CD4+ T cell responses
- Protein Kinase D1 Phosphorylates HDAC7 and Induces Its Nuclear Export after T-cell Receptor Activation*
- Histone-deacetylase inhibitors: novel drugs for the treatment of cancer
- Acetylation and deacetylation of non-histone proteins.
- Trichostatin A attenuates airway inflammation in mouse asthma model
- Experimental models of inflammatory bowel disease reveal innate, adaptive, and regulatory mechanisms of host dialogue with the microbiota
- Enzyme Linked Immunosorbent Spot (ELISPOT) Assay for Interferon‐Gamma Independently Predicts Renal Function in Kidney Transplant Recipients
- Class II histone deacetylases act as signal-responsive repressors of cardiac hypertrophy.
- Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1
- Cardiac histone acetylation--therapeutic opportunities abound.
- Histone Deacetylases as Transcriptional Activators? Role Reversal in Inducible Gene Regulation
- An essential role for Scurfin in CD4+CD25+ T regulatory cells
- B7‐H3 promotes acute and chronic allograft rejection
- Involvement of CD4+ T cells in the development of dextran sulfate sodium-induced experimental colitis and suppressive effect of IgG on their action.
Cited by
- Inhibition of Histone Deacetylases in Inflammatory Bowel Diseases
- Epigenetic changes in inflammatory and autoimmune diseases.
- Clinical application of regulatory T cells for treatment of type 1 diabetes and transplantation
- Epigenetic Regulation of Foxp3 Expression in Regulatory T Cells by DNA Methylation
- Concerted Dysregulation of 5 Major Classes of Blood Leukocyte Genes in Diabetic ZDF Rats: A Working Translational Profile of Comorbid Rheumatoid Arthritis Progression
- Epigenetic mechanisms and the relationship to childhood asthma
- HDAC Inhibition in Lupus Models
- Helios Expression Is a Marker of T Cell Activation and Proliferation
- Histone deacetylase inhibition activates transcription factor Nrf2 and protects against cerebral ischemic damage
- Three novel acetylation sites in the Foxp3 transcription factor regulate the suppressive activity of regulatory T cells
- Transcription factor Foxp3 and its protein partners form a complex regulatory network
- Histone deacetylases inhibitor Trichostatin A ameliorates DNFB-induced allergic contact dermatitis and reduces epidermal Langerhans cells in mice
- Epigenetics in sepsis: targeting histone deacetylases.
- Combining HDAC inhibitors with oncolytic virotherapy for cancer therapy
- Therapeutic Potential of Targeting the Th17/Treg Axis in Autoimmune Disorders
- Impacto de los inhibidores de Deacetilasas de Histonas (iHDAC) sobre la funcionalidad de células NK
- The Biology of FoxP3: A Key Player in Immune Suppression during Infections, Autoimmune Diseases and Cancer
- Targeting deacetylases to improve outcomes after allogeneic bone marrow transplantation.
- Histone Deacetylases as Targets for Melanoma Immunotherapy
- The molecular regulation of Forkhead box P3
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