Critical Review of Non-Histone Human Substrates of Metal-Dependent Lysine Deacetylases
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Summary
This critical analysis of the literature identifies 108 proposed non‐histone substrate‐KDAC pairs for which direct experimental evidence has been reported and presents a path forward for evaluating the remaining substrate leads and reliably identifying novel KDAC substrates.
- Type
- review
- Published
- 2020-08-30
- Cited by
- 11
- References
- 124
- Access
- Open access
- OpenAlex
- https://openalex.org/W3081939280
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:221383344
Keywords
Acetylation, Lysine, Histone, Enzyme, Biochemistry
References
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- Shaping the nuclear action of NF-κB
- Deacetylation of HSPA5 by HDAC6 leads to GP78-mediated HSPA5 ubiquitination at K447 and suppresses metastasis of breast cancer
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- AMPK-HDAC5 pathway facilitates nuclear accumulation of HIF-1α and functional activation of HIF-1 by deacetylating Hsp70 in the cytosol
- SPRR2A enhances p53 deacetylation through HDAC1 and down regulates p21 promoter activity
- NF-κB Activation, Dependent on Acetylation/Deacetylation, Contributes to HIF-1 Activity and Migration of Bone Metastatic Breast Carcinoma Cells
- Sumoylation and Acetylation Play Opposite Roles in the Transactivation of PLAG1 and PLAGL2*
- Activation and Inhibition of Histone Deacetylase 8 by Monovalent Cations*
- Lysine acetylation activates 6-phosphogluconate dehydrogenase to promote tumor growth
- Histone Deacetylase 6 (HDAC6) Deacetylates Survivin for Its Nuclear Export in Breast Cancer*
- Structural and Functional Analysis of the Human HDAC4 Catalytic Domain Reveals a Regulatory Structural Zinc-binding Domain*
- HDAC‐6 interacts with and deacetylates tubulin and microtubules in vivo
- Proteomic identification and functional characterization of MYH9, Hsc70, and DNAJA1 as novel substrates of HDAC6 deacetylase activity
- Enhanced Deacetylation of p53 by the Anti-apoptotic Protein HSCO in Association with Histone Deacetylase 1*
- Regulation of STAT3 by histone deacetylase-3 in diffuse large B-cell lymphoma: implications for therapy
- Histone Deacetylase 9 (HDAC9) Regulates the Functions of the ATDC (TRIM29) Protein*
- HDAC6 regulates Hsp90 acetylation and chaperone-dependent activation of glucocorticoid receptor.
Cited by
- Roles of Histone Deacetylases in Acute Myeloid Leukemia With Fusion Proteins
- Genetic screen for suppressors of increased silencing in rpd3 mutants in Saccharomyces cerevisiae identifies a potential role for H3K4 methylation
- Inhibition of Histone Deacetylase 6 (HDAC6) as a therapeutic strategy for Alzheimer's disease: A review (2010-2020).
- Characterization of the class IIa histone deacetylases substrate specificity
- Tubulin Post-Translational Modifications: The Elusive Roles of Acetylation
- Endogenous expression of inactive lysine deacetylases reveals deacetylation-dependent cellular mechanisms
- Acetylation and Phosphorylation in the Regulation of Hypoxia-Inducible Factor Activities: Additional Options to Modulate Adaptations to Changes in Oxygen Levels
- Lysine deacetylase inhibitors have low selectivity in cells and exhibit predominantly off‐target effects
- Development of novel benzamide class I selective lysine deacetylase inhibitors as potent anticancer agents
- GRK5 Overexpression Drives Malignant Glioma Progression Through HDAC7 Alongside Canonical GPCR Signaling
- Acetylation and Phosphorylation in the Regulation of Hypoxia-Inducible Factors Activities: Additional Options to Modulate Adaptations to Changes in Oxygen Levels
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