Enzyme Linked Immunosorbent Spot (ELISPOT) Assay for Interferon‐Gamma Independently Predicts Renal Function in Kidney Transplant Recipients
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Summary
Increased levels of early alloreactivity measured with this ELISPOT assay may serve as a surrogate for chronic allograft dysfunction and show an independent correlation between early cellular allore activity and long‐term renal function.
- Type
- article
- Published
- 2003-07-01
- Cited by
- 198
- References
- 31
- Access
- Open access
- OpenAlex
- https://openalex.org/W1994121614
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:2722384
Keywords
ELISPOT, Medicine, Creatinine, Transplantation, Kidney transplantation
References
- Characterization of in vivo-activated allospecific T lymphocytes propagated from human renal allograft biopsies undergoing rejection.
- The emerging role of gene polymorphisms determining outcome after solid‐organ transplantation
- Pretransplant frequency of donor-specific, IFN-gamma-producing lymphocytes is a manifestation of immunologic memory and correlates with the risk of posttransplant rejection episodes.
- High frequency and nonrandom distribution of alloreactivity in T cell clones selected for recognition of foreign antigen in association with self class II molecules.
- Identification of clinical and histopathologic risk factors for diminished renal function 2 years posttransplant.
- INCREASED IMPACT OF ACUTE REJECTION ON CHRONIC ALLOGRAFT FAILURE IN RECENT ERA
- Kidney graft failure and presensitization against HLA Class I and Class II antigens1
- Impact of acute rejection and early allograft function on renal allograft survival.
- Persistent allopeptide reactivity and epitope spreading in chronic rejection of organ allografts.
- Genetic polymorphisms and transplantation.
- Five preventable causes of kidney graft loss in the 1990s: a single-center analysis.
- CORRELATION OF NONSPECIFIC IMMUNE MONITORING WITH REJECTION OR IMPAIRED FUNCTION OF RENAL ALLOGRAFTS
- Indirect allorecognition of major histocompatibility complex allopeptides in human renal transplant recipients with chronic graft dysfunction.
- The Inevitability of Renal Function Loss in Patients with Hypercreatinemia
- Clinical Significance of MHC‐Reactive Alloantibodies that Develop after Kidney or Kidney–pancreas Transplantation
- Reversibility with interleukin-2 suggests that T cell anergy contributes to donor-specific hyporesponsiveness in renal transplant patients.
- Loss of Direct and Maintenance of Indirect Alloresponses in Renal Allograft Recipients: Implications for the Pathogenesis of Chronic Allograft Nephropathy1
- Relationships between arterial hypertension and renal allograft survival in African-American patients.
- Immune monitoring in kidney transplant recipients revisited.
- Evolution of the Enzyme‐Linked Immunosorbent Spot Assay for Post‐Transplant Alloreactivity as a Potentially Useful Immune Monitoring Tool
Cited by
- Heterogeneous Alterations in Human Alloimmunity Associated with Immunization
- Zastosowanie algorytmu hit-miss do segmentacji barwnych obrazów mikroskopowych w badaniu metodą ELISPOT
- Prediction modeling of kidney transplant outcome
- Phenotypic and Transcriptional Biomarkers In Organ Transplantation
- Zastosowanie algorytmów progowania adaptacyjnego do segmentacji barwnych obrazów mikroskopowych w badaniu metodą ELISPOT
- Treg Therapy in Transplantation: How and When Will We Do It?
- Pre-transplant donor-specific Interferon-gamma-producing cells and acute rejection of the kidney allograft.
- Biomarkers to assess donor-reactive T-cell responses in kidney transplant patients.
- Investigations into the outcomes of HLA antibody incompatible renal transplantation and the influence of immune memory
- 25-OH-Vitamin D deficiency and cellular alloimmunity as measured by panel of reactive T cell testing in dialysis patients
- CD8 T Cells Specific for a Donor-Derived, Self-Restricted Transplant Antigen Are Nonpathogenic Bystanders after Vascularized Heart Transplantation in Mice1
- Dynamic Changes of IFN-γ-producing Cells, TGF-β and Their Preidctive Value in Early Outcomees of Renal Transplantation
- Allo‐induced Acute‐phase Response; IL‐6 Identifies a Subset of Individuals at Risk for Graft Injury
- Achieving Donor-Specific Hyporesponsiveness Is Associated with FOXP3+ Regulatory T Cell Recruitment in Human Renal Allograft Infiltrates1
- System analizy obrazów uzyskiwanych w immunoenzymatycznej wizualizacji aktywności wydzielniczej limfocytów metodą ELISPOT
- Effects of T Cell Frequency and Graft Size on Transplant Outcome in Mice 1
- Cutting Edge: Acute Lung Allograft Rejection Is Independent of Secondary Lymphoid Organs1
- Follicular T helper cells and humoral reactivity in kidney transplant patients
- Interferon Gamma ELISPOT Testing as a Risk-stratifying Biomarker for Kidney Transplant Injury: Results from the CTOT-01 Multicenter Study
- Multicenter Analysis of Immune Biomarkers and Heart Transplant Outcomes
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