The histone deacetylase inhibitor Trichostatin A modulates CD4+ T cell responses
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Summary
Findings indicate that HDAC inhibitors have an immunomodulatory potential that may contribute to the potency and specificity of these antineoplastic compounds and might be useful in the treatment of autoimmune disorders.
- Type
- article
- Published
- 2003-11-09
- Cited by
- 150
- References
- 73
- Access
- Open access
- OpenAlex
- https://openalex.org/W1790486867
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:17968445
Keywords
Trichostatin A, Histone deacetylase, Histone deacetylase inhibitor, Surgical oncology, Medicine
References
- Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer
- CTLA-4 Ligation Suppresses CD28-induced NF-κB and AP-1 Activity in Mouse T Cell Blasts*
- Antineoplastic action of 5-aza-2′-deoxycytidine and histone deacetylase inhibitor and their effect on the expression of retinoic acid receptor β and estrogen receptor α genes in breast carcinoma cells
- Up-regulation of costimulatory/adhesion molecules by histone deacetylase inhibitors in acute myeloid leukemia cells.
- Histone deacetylase inhibitors as potential anti-skin cancer agents.
- Histone deacetylase inhibitors suppress IL-2-mediated gene expression prior to induction of apoptosis.
- IL-15 and IL-2: a matter of life and death for T cells in vivo
- Role of the histone deacetylase complex in acute promyelocytic leukaemia
- The expression of a small fraction of cellular genes is changed in response to histone hyperacetylation.
- Induction of caspase-3 protease activity and apoptosis by butyrate and trichostatin A (inhibitors of histone deacetylase): dependence on protein synthesis and synergy with a mitochondrial/cytochrome c-dependent pathway.
- Histone methylation versus histone acetylation: new insights into epigenetic regulation.
- Inhibition of histone deacetylase activity by trichostatin A modulates gene expression during mouse embryogenesis without apparent toxicity.
- The histone deacetylase inhibitor and chemotherapeutic agent suberoylanilide hydroxamic acid (SAHA) induces a cell-death pathway characterized by cleavage of Bid and production of reactive oxygen species
- B-cell surface antigen B7 provides a costimulatory signal that induces T cells to proliferate and secrete interleukin 2.
- Distinct interactions of PML-RARα and PLZF-RARα with co-repressors determine differential responses to RA in APL
- Protein modules that manipulate histone tails for chromatin regulation
- DNA methylation and histone deacetylation associated with silencing DAP kinase gene expression in colorectal and gastric cancers
- Oxamflatin is a novel antitumor compound that inhibits mammalian histone deacetylase
- Histone Hyperacetylation Induced by Histone Deacetylase Inhibitors Is Not Sufficient to Cause Growth Inhibition in Human Dermal Fibroblasts*
- Role of covalent modifications of histones in regulating gene expression.
Cited by
- Inhibition of Histone Deacetylases in Inflammatory Bowel Diseases
- Mechanism of Action for HDAC Inhibitors—Insights from Omics Approaches
- Impacto de los inhibidores de Deacetilasas de Histonas (iHDAC) sobre la funcionalidad de células NK
- Histone Deacetylase Inhibitors Trichostatin A (tsa) And Sulforaphane (sfn) Modulate Vitamin D Responsive Cyp24 Gene Expression in 3t3-l1 Preadipocytes
- Rationale for HDAC inhibitor therapy in autoimmunity and transplantation.
- IL-23 is pro-proliferative, epigenetically regulated and modulated by chemotherapy in non-small cell lung cancer.
- HDAC inhibitors and immunotherapy; a double edged sword?
- Coordinated histone H3 methylation and acetylation regulates physiologic and pathologic Fas Ligand gene expression in human CD4+ T cells
- Conditional Deletion of Histone Deacetylase 1 in T Cells Leads to Enhanced Airway Inflammation and Increased Th2 Cytokine Production
- Is targeted chemotherapy an alternative to immunotherapy in chronic lymphocytic leukemia?
- Apicidin decreases phospholipase C gamma-1 transcript and protein in Hut-78 T lymphoma cells.
- Histone deacetylase regulation of immune gene expression in tumor cells
- Suppression of T cell functions by hydroxamic acid-based histone deacetylase inhibitors
- Evaluating epigenetic landmarks in the brain of multiple sclerosis patients: A contribution to the current debate on disease pathogenesis
- Reduced CD4+ T-cell-specific gene expression in human type 1 diabetes mellitus.
- Cell‐surface expression of Hsp70 on hematopoietic cancer cells after inhibition of HDAC activity
- Trichostatin Differentially Regulates Th1 and Th2 Responses and Alleviates Rheumatoid Arthritis in Mice
- Manipulation of B-cell responses with histone deacetylase inhibitors
- Trichostatin A attenuates airway inflammation in mouse asthma model
- Enhancement of Vaccinia Virus Based Oncolysis with Histone Deacetylase Inhibitors
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