Immune regulation by histone deacetylases: a focus on the alteration of FOXP3 activity
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Summary
By understanding the details of the biochemical and structural basis of the regulation of FOXP3 acetylation, therapeutic strategies for diseases related to Treg cells may emerge.
- Type
- review
- Published
- 2011-11-29
- Cited by
- 47
- References
- 66
- Access
- Open access
- OpenAlex
- https://openalex.org/W2139008546
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:37096313
Keywords
FOXP3, Immune system, Transcription factor, Histone, Cell biology
References
- Acetylation and deacetylation of non‐histone proteins
- Control of muscle development by dueling HATs and HDACs.
- The structural basis of protein acetylation by the p300/CBP transcriptional coactivator
- The NuRD complex: linking histone modification to nucleosome remodeling.
- The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3
- X-linked lymphoreticular disease in the scurfy (sf) mutant mouse.
- X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy
- Molecular Mechanisms Underlying FOXP3 Induction in Human T Cells1
- Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse
- Analysis of FOXP3 Reveals Multiple Domains Required for Its Function as a Transcriptional Repressor1
- The transcriptional corepressor MITR is a signal-responsive inhibitor of myogenesis
- Three Distinct Domains Contribute to Nuclear Transport of Murine Foxp3
- Foxp3 interacts with nuclear factor of activated T cells and NF-kappa B to repress cytokine gene expression and effector functions of T helper cells.
- Degradation of cyclin A is regulated by acetylation
- Special regulatory T‐cell review: FOXP3 biochemistry in regulatory T cells – how diverse signals regulate suppression
- JM2, encoding a fork head-related protein, is mutated in X-linked autoimmunity-allergic disregulation syndrome.
- Acetylation and deacetylation of non-histone proteins.
- Splicing of HDAC7 modulates the SRF-myocardin complex during stem-cell differentiation towards smooth muscle cells
- Protein kinase C‐related kinase targets nuclear localization signals in a subset of class IIa histone deacetylases
- Valproate Treatment of Human Cord Blood CD4-positive Effector T Cells Confers on Them the Molecular Profile (MicroRNA Signature and FOXP3 Expression) of Natural Regulatory CD4-positive Cells through Inhibition of Histone Deacetylase*
Cited by
- Histone deacetylases (HDACs) as mediators of resistance to apoptosis in melanoma and as targets for combination therapy with selective BRAF inhibitors.
- Gut microbial short-chain fatty acids in host defense and immune regulation
- Pim-2 Kinase Influences Regulatory T Cell Function and Stability by Mediating Foxp3 Protein N-terminal Phosphorylation*
- Regulatory T-cells and micrometastasis in lymph nodes of stage I NSCLC.
- Epigenetic modulation with histone deacetylase inhibitors in combination with immunotherapy.
- The plasticity and stability of regulatory T cells
- Heat Shock Proteins and Regulatory T Cells
- Class I and II Histone Deacetylase Inhibition by ITF2357 Reduces SLE Pathogenesis In Vivo
- Metabolites produced by commensal bacteria promote peripheral regulatory T cell generation
- Molecular and biological role of the FOXP3 N-terminal domain in immune regulation by T regulatory/suppressor cells
- Forkhead box P3: The Peacekeeper of the Immune System
- Anatomical localization of commensal bacteria in immune cell homeostasis and disease
- Modulation of Treg function improves adenovirus vector-mediated gene expression in the airway
- Histone deacetylase (HDAC) inhibitors with a novel connecting unit linker region reveal a selectivity profile for HDAC4 and HDAC5 with improved activity against chemoresistant cancer cells.
- Forkhead box proteins: tuning forks for transcriptional harmony.
- Lysosome-dependent p300/FOXP3 degradation and limits Treg cell functions and enhances targeted therapy against cancers
- mTORC2-PKBα/Akt1 Serine 473 phosphorylation axis is essential for regulation of FOXP3 Stability by chemokine CCL3 in psoriasis.
- Regulatory T cells and transplantation tolerance.
- Indoleamine 2,3-Dioxygenase as A Prognostic Factor in Patients with Non-Small Cell Lung Cancer
- Clinical significance of the frequency of regulatory T cells in regional lymph node lymphocytes as a prognostic factor for non-small-cell lung cancer.
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