Modulation of Treg function improves adenovirus vector-mediated gene expression in the airway
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Summary
The use of an HDAC inhibitor, valproic acid (VPA), is reported to enhance the activity of the regulatory T cells (Treg) and to improve the expression of virus vector-mediated gene transfer to the respiratory epithelium.
- Type
- article
- Published
- 2014-01-02
- Cited by
- 8
- References
- 47
- Access
- Open access
- OpenAlex
- https://openalex.org/W2041725607
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:2426158
Keywords
Cystic fibrosis transmembrane conductance regulator, Genetic enhancement, Cystic fibrosis, Biology, Immunology
References
- The histone deacetylase inhibitor Trichostatin A modulates CD4+ T cell responses
- Improved therapeutic effect on malignant glioma with adenoviral suicide gene therapy combined with temozolomide
- Blunting of immune responses to adenoviral vectors in mouse liver and lung with CTLA4Ig
- Gene and cell therapy for cystic fibrosis: from bench to bedside.
- Gene therapy in cystic fibrosis.
- Identification of the cystic fibrosis gene: Cloning and characterization of complementary DNA
- Correction of the cystic fibrosis defect in vitro by retrovirus-mediated gene transfer.
- Inflammatory cytokines in cystic fibrosis lungs.
- FOXP3 Actively Represses Transcription by Recruiting the HAT/HDAC Complex
- Adeno-associated virus serotype 9 vectors transduce murine alveolar and nasal epithelia and can be readministered
- An Animal Model for Cystic Fibrosis Made by Gene Targeting
- HDAC inhibitor‐based therapies: Can we interpret the code?
- Immunological hurdles to lung gene therapy
- Expression of cystic fibrosis transmembrane conductance regulator corrects defective chloride channel regulation in cystic fibrosis airway epithelial cells
- Regulation of Treg functionality by acetylation-mediated Foxp3 protein stabilization.
- Functional immunoregulatory T-cell abnormalities in cystic fibrosis patients
- Adaptive Foxp3+ regulatory T cell-dependent and -independent control of allergic inflammation.
- Cystic fibrosis: a mucosal immunodeficiency syndrome
- Histone acetyltransferase mediated regulation of FOXP3 acetylation and Treg function
- Biochemistry and therapeutic implications of mechanisms involved in FOXP3 activity in immune suppression.
Cited by
- Anti-fibrotic effects of valproic acid: role of HDAC inhibition and associated mechanisms.
- Inhibition of histone-deacetylase activity rescues inflammatory cystic fibrosis lung disease by modulating innate and adaptive immune responses
- FOXP3 and Its Cofactors as Targets of Immunotherapies
- Exploring the Drug Repurposing Versatility of Valproic Acid as a Multifunctional Regulator of Innate and Adaptive Immune Cells
- Targeting FOXP3 complex ensemble in drug discovery.
- Regulatory T cells are a double-edged sword in pulmonary fibrosis.
- Valproic Acid Suppresses Autoimmune Recurrence and Allograft Rejection in Islet Transplantation through Induction of the Differentiation of Regulatory T Cells and Can Be Used in Cell Therapy for Type 1 Diabetes
- 作为免疫疗法靶点的 FOXP3 及其辅因子
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