Degradation of cyclin A is regulated by acetylation
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Summary
It is reported that the acetyltransferase P/CAF directly interacts with cyclin A that as a consequence becomes acetylated at lysines 54, 68, 95 and 112, indicating importance of acetylation oncyclin A stability and also in the regulation of cycA-cdk activity.
- Type
- article
- Published
- 2009-06-01
- Cited by
- 60
- References
- 43
- Access
- Open access
- OpenAlex
- https://openalex.org/W1967425351
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:22464892
Keywords
Cyclin A, Cyclin-dependent kinase, Biology, Cyclin A2, Cell biology
References
- To cell cycle, swing the APC/C.
- The ‘destruction box’ of cyclin A allows B‐type cyclins to be ubiquitinated, but not efficiently destroyed.
- The PCAF acetylase complex as a potential tumor suppressor.
- Regulation and destabilization of HIF-1alpha by ARD1-mediated acetylation.
- Trichostatin A increases the thermosensitivity of human glioblastoma A172 cells.
- Identification of an Hexapeptide That Binds to a Surface Pocket in Cyclin A and Inhibits the Catalytic Activity of the Complex Cyclin-dependent Kinase 2-Cyclin A*
- DNA damage activates p53 through a phosphorylation-acetylation cascade.
- Dual mode of degradation of Cdc25 A phosphatase
- Cyclin is degraded by the ubiquitin pathway
- Histone H3 and H4 N-termini interact with SIR3 and SIR4 proteins: a molecular model for the formation of heterochromatin in yeast.
- Intrinsic ubiquitination activity of PCAF controls the stability of the oncoprotein Hdm2
- Finishing mitosis, one step at a time
- Direct binding of CDC20 protein family members activates the anaphase-promoting complex in mitosis and G1.
- Regulation of protein turnover by acetyltransferases and deacetylases.
- The APC/C maintains the spindle assembly checkpoint by targeting Cdc20 for destruction
- Anaphase-Promoting Complex/Cyclosome–Dependent Proteolysis of Human Cyclin a Starts at the Beginning of Mitosis and Is Not Subject to the Spindle Assembly Checkpoint
- Acetylation of general transcription factors by histone acetyltransferases.
- Regulation of E2F-1 after DNA Damage by p300-Mediated Acetylation and Ubiquitination
- Distinct GCN5/PCAF-containing complexes function as co-activators and are involved in transcription factor and global histone acetylation
- The N-terminal Regulatory Domain of Cyclin A Contains Redundant Ubiquitination Targeting Sequences and Acceptor Sites
Cited by
- Gcn5 determines the fate of Drosophila germline stem cells through degradation of Cyclin A
- Suppression of cell cycle progression by Jun dimerization protein (JDP2) involves down-regulation of cyclin A2
- Histone deacetylase inhibitors disrupt the mitotic spindle assembly checkpoint by targeting histone and nonhistone proteins.
- Global analysis of histone variant H2A.Z acetylation in Saccharomyces cerevisiae
- The Human Cytomegalovirus Protein pUL21a Binds to and Degrades Cyclin A via the Proteasome
- Acetylations of Ftz-F1 and histone H4K5 are required for the fine-tuning of ecdysone biosynthesis during Drosophila metamorphosis.
- Acetylation mediates Cx43 reduction caused by electrical stimulation
- Acetylation controls Notch3 stability and function in T-cell leukemia
- L-Carnitine Is an Endogenous HDAC Inhibitor Selectively Inhibiting Cancer Cell Growth In Vivo and In Vitro
- Fifteen years of APC/cyclosome: a short and impressive biography.
- High-resolution live-cell imaging reveals novel cyclin A2 degradation foci involving autophagy
- Histone Deacetylase 3 Regulates Cyclin A Stability*
- Acetylation-Mediated Proteasomal Degradation of Core Histones during DNA Repair and Spermatogenesis
- CYCLINg through transcription
- NudC Deacetylation Regulates Mitotic Progression
- Acetylation of cyclin A: a new cell cycle regulatory mechanism.
- Acetylation of RNA Processing Proteins and Cell Cycle Proteins in Mitosis
- An Intron-Retaining Splice Variant of Human Cyclin A2, Expressed in Adult Differentiated Tissues, Induces a G1/S Cell Cycle Arrest In Vitro
- Tuning acetylated chromatin with HAT inhibitors: A novel tool for therapy
- Substrate-specific regulation of ubiquitination by the anaphase-promoting complex
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