How antibiotics kill bacteria: from targets to networks
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Summary
The multilayered effects of drug–target interactions, including the essential cellular processes that are inhibited by bactericidal antibiotics and the associated cellular response mechanisms that contribute to killing are discussed.
- Type
- review
- Published
- 2010-05-04
- Cited by
- 2,192
- References
- 155
- OpenAlex
- https://openalex.org/W2128912763
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:12354260
Keywords
Biology, Antibiotics, Computational biology, Bacteria, Drug
References
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- RecA-dependent recovery of arrested DNA replication forks.
- Two bactericidal targets for penicillin in pneumococci: autolysis-dependent and autolysis-independent killing mechanisms
- Structure of the A Site of Escherichia coli 16S Ribosomal RNA Complexed with an Aminoglycoside Antibiotic
Cited by
- Biosensors, antibiotics and food.
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- RNA modifications by oxidation: a novel disease mechanism?
- Investigation of antimicrobials from native British plants used in 10th century Anglo-Saxon wound healing formulations
- Structure-Based Gene Targeting Discovery of a Novel Bacterial Translocase I Inhibitor, Sphaerimicin
- Single-cell, real-time detection of oxidative stress induced in Escherichia coli by the antimicrobial peptide CM15
- Shaping Nanoparticles with Hydrophilic Compositions and Hydrophobic Properties as Nanocarriers for Antibiotic Delivery
- Pharmacological evaluation of poly(3-methylthiophene) and its titanium(IV)phosphate nanocomposite: DNA interaction, molecular docking, and cytotoxic activity.
- Quinolone Resistance Reversion by Targeting the SOS Response
- Glutathione Enhances Antibiotic Efficiency and Effectiveness of DNase I in Disrupting Pseudomonas aeruginosa Biofilms While Also Inhibiting Pyocyanin Activity, Thus Facilitating Restoration of Cell Enzymatic Activity, Confluence and Viability
- Drugging tRNA aminoacylation
- Response of ginger growth to a tetracycline-contaminated environment and residues of antibiotic and antibiotic resistance genes.
- The antimicrobial action of polyaniline involves production of oxidative stress while functionalisation of polyaniline introduces additional mechanisms
- Mechanical Genomic Studies Reveal the Role of d-Alanine Metabolism in Pseudomonas aeruginosa Cell Stiffness
- Transcriptional Landscape of a blaKPC-2 Plasmid and Response to Imipenem Exposure in Escherichia coli TOP10
- Enhanced NADH Metabolism Involves Colistin-Induced Killing of Bacillus subtilis and Paenibacillus polymyxa
- Anti-infective potential of hydroalcoholic extract of Punica granatum peel against gram-negative bacterial pathogens
- Electrochemical control of bacterial persister cells
- Genotypic and phenotypic characterisation of Staphylococcus epidermidis isolated from prosthetic joint infections
- Cambios en la fisiología de Pseudomonas aeruginosa causados por la sobre-expresión del sistema múltiple de bombeo MexEF-OprN
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