Quinolone Resistance Reversion by Targeting the SOS Response
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Summary
Evaluating the impact of suppression of the SOS response using a model of isogenic strains of Escherichia coli representing multiple levels of quinolone resistance found it to reverses antimicrobial resistance across a range of E. coli phenotypes from reduced susceptibility to highly resistant, playing a significant role in increasing the in vivo efficacy.
- Type
- article
- Published
- 2017-10-10
- Cited by
- 66
- References
- 54
- OpenAlex
- https://openalex.org/W29018116
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:19598253
Keywords
Political science
References
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- The frequency and structure of recombinant products is determined by the cellular level of MutL
- Microbiological effects of sublethal levels of antibiotics
- The SOS response promotes qnrB quinolone‐resistance determinant expression
- Engineered bacteriophage targeting gene networks as adjuvants for antibiotic therapy
- Adherence to abiotic surface induces SOS response in Escherichia coli K-12 strains under aerobic and anaerobic conditions.
Cited by
- Advancement of the 5-Amino-1-(Carbamoylmethyl)-1H-1,2,3-Triazole-4-Carboxamide Scaffold to Disarm the Bacterial SOS Response
- Inhibitors of LexA autoproteolysis and the bacterial SOS response discovered by an academic-industry partnership
- DNA Damage Repair and Drug Efflux as Potential Targets for Reversing Low or Intermediate Ciprofloxacin Resistance in E. coli K-12
- Quantifying the contribution of four resistance mechanisms to ciprofloxacin minimum inhibitory concentration in Escherichia coli: a systematic review
- Gene Expression Dynamics Induced by Ciprofloxacin and Loss of Lexa Function in Pseudomonas Aeruginosa PAO1 Using Data Mining and Network Analysis
- The antioxidant drug N-acetylcysteine abolishes SOS-mediated mutagenesis produced by fluoroquinolones in bacteria
- Suppression of the SOS response modifies spatiotemporal evolution, post-antibiotic effect, bacterial fitness and biofilm formation in quinolone-resistant Escherichia coli
- The landscape of intrinsic and evolved fluoroquinolone resistance in Acinetobacter baumannii includes suppression of drug-induced prophage replication
- Distinct transcriptomic response of S. coelicolor to ciprofloxacin in a nutrient-rich environment
- Quantifying the contribution of four resistance mechanisms to ciprofloxacin MIC in Escherichia coli: a systematic review
- Zinc Blockade of SOS Response Inhibits Horizontal Transfer of Antibiotic Resistance Genes in Enteric Bacteria
- The SOS Response Mediates Sustained Colonization of the Mammalian Gut
- Dissemination of Escherichia coli carrying plasmid-mediated quinolone resistance (PMQR) genes from swine farms to surroundings.
- Small open reading frames and cellular stress responses
- Betulinic Acid Prevents the Acquisition of Ciprofloxacin-Mediated Mutagenesis in Staphylococcus aureus
- N-acetylcysteine blocks SOS induction and mutagenesis produced by fluoroquinolones in Escherichia coli.
- The Landscape of Phenotypic and Transcriptional Responses to Ciprofloxacin in Acinetobacter baumannii: Acquired Resistance Alleles Modulate Drug-Induced SOS Response and Prophage Replication
- Expression of different ParE toxins results in conserved phenotypes with distinguishable classes of toxicity
- A ParDE-family toxin antitoxin system in major resistance plasmids of Enterobacteriaceae confers antibiotic and heat tolerance
- Non-Canonical Functions Of The Bacterial Sos Response
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