Two bactericidal targets for penicillin in pneumococci: autolysis-dependent and autolysis-independent killing mechanisms
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Summary
It is concluded that penicillin kills pneumococci by two distinct mechanisms: one that involves the triggering of the amidase (about 1 log unit of killing per 6 h) and another, amidase-independent mechanism that is responsible for 3 to 4 log units of killingper 6 h.
- Type
- article
- Published
- 1990-01-01
- Cited by
- 95
- References
- 25
- Access
- Open access
- OpenAlex
- https://openalex.org/W1965240731
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:25907979
Keywords
Amidase, Autolysis (biology), Penicillin amidase, Microbiology, Penicillin
References
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- Alteration of Escherichia coli murein during amino acid starvation
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- Mechanism of action of penicillin: triggering of the pneumococcal autolytic enzyme by inhibitors of cell wall synthesis.
- Penicillin tolerance in multiply drug-resistant natural isolates of Streptococcus pneumoniae.
- Penicillin resistance and defective lysis in clinical isolates of pneumococci: evidence for two kinds of antibiotic pressure operating in the clinical environment.
- A procedure for the isolation of deoxyribonucleic acid from micro-organisms
- Tolerant Response of Streptococcus sanguis to Beta-Lactams and Other Cell Wall Inhibitors
- A rapid procedure to detect the autolysin phenotype in Streptococcus pneumoniae
- Marker discrimination in transformation and mutation of pneumococcus.
- Absence of autolytic activity (peptidoglycan nicking) in penicillin-induced nonlytic death in a group A streptococcus
- Model for the Mechanism Controlling the Expression of Competent State in Pneumococcus Cultures
- A new peptidoglycan hydrolase in Streptococcus pneumoniae
- Preparation of antiserum against the pneumococcal autolysin—inhibition of autolysin activity and some autolytic processes by the antibody
Cited by
- The two‐step lysis system of pneumococcal bacteriophage EJ‐1 is functional in Gram‐negative bacteria: triggering of the major pneumococcal autolysin in Escherichia coli
- Antimicrobial Resistant Streptococcus pneumoniae Infections: Clinical and Epidemiological Trends
- Mechanism of vancomycin resistance in methicillin resistant Staphylococcus aureus.
- Etude fonctionnelle de Pmp23, une nouvelle enzyme de clivage du peptidoglycane chez Streptococcus pneumoniae
- Bacillus Subtilis Extracytoplasmic Function Sigma Factors Control Antibiotic Production And Resistance
- Antibiotic-Dependent Correlation Between Drug-Induced Killing and Loss of Luminescence in Streptococcus gordonii Expressing Luciferase
- Death's toolbox: examining the molecular components of bacterial programmed cell death
- Genetic approaches towards understanding penumococcal virulence and biology
- Opposing Roles of the Staphylococcus aureus Virulence Regulators, Agr and Sar, in Triton X-100- and Penicillin-Induced Autolysis
- Emergence of vancomycin tolerance in Streptococcus pneumoniae
- Antibiotic tolerance in pneumococci.
- Pneumococcal pili and other cell surface properties affect the infection biology of Streptococcus pneumoniae
- Pneumococcal resistance to antibiotics
- Amoxicillin dose-effect relationship with Streptococcus pneumoniae in a mouse pneumonia model and roles of in vitro penicillin susceptibilities, autolysis, and tolerance properties of the strains
- Loss of Antibiotic Tolerance in Sod-Deficient Mutants Is Dependent on the Energy Source and Arginine Catabolism in Enterococci
- The etiology of respiratory tract infections and the antibacterial activity of fluoroquinolones and other oral antibacterial agents against respiratory pathogens.
- Bases molculaires de la rsistance du pneumocoque aux -lactamines
- Cell envelope stress response in Gram-positive bacteria.
- Mechanisms of antibiotic resistance and tolerance in Streptococcus pneumoniae.
- Pharmacodynamics of Antibiotics-Consequences for Dosing: Proceedings of a Symposium Held in Stockholm, June 7–9, 1990
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