Histone Modifications at Human Enhancers Reflect Global Cell Type-Specific Gene Expression
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Summary
The results define over 55,000 potential transcriptional enhancers in the human genome, significantly expanding the current catalogue of human enhancers and highlighting the role of these elements in cell-type-specific gene expression.
- Type
- article
- Published
- 2009-03-01
- Cited by
- 2,530
- References
- 36
- Access
- Open access
- OpenAlex
- https://openalex.org/W2123564569
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:4422770
Keywords
Enhancer, Biology, Chromatin, Chromatin immunoprecipitation, Promoter
References
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- Histone modifications: signalling receptors and potential elements of a heritable epigenetic code.
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- Discovery of functional elements in 12 Drosophila genomes using evolutionary signatures
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- Genome-Wide Mapping of in Vivo Protein-DNA Interactions
- The t-PA -7351C>T enhancer polymorphism decreases Sp1 and Sp3 protein binding affinity and transcriptional responsiveness to retinoic acid.
Cited by
- Regulation of Adipocyte Transcription by PPARgamma Ligands
- Functional analysis of human enhancers using the zebrafish embryo
- Interactions of transcription factors with chromatin.
- Chromatin Insulators: Master Regulators of the Eukaryotic Genome
- Maternal diet, aging and diabetes meet at a chromatin loop
- Close encounters of the 3C kind: long-range chromatin interactions and transcriptional regulation.
- Discovery and Annotation of Functional Chromatin Signatures in the Human Genome
- Developmental gene regulation in the era of genomics.
- The tumor suppressor role of CTCF
- Discriminative prediction of mammalian enhancers from DNA sequence.
- Histone tail acetylation in brain occurs in an unpredictable fashion after death
- Coding exons function as tissue-specific enhancers of nearby genes
- Lineage-specific adjacent IFNG and IL26 genes share a common distal enhancer element
- Epigenetics and chromatin dynamics: a review and a paradigm for functional disorders
- Essential role of the IRF8-KLF4 transcription factor cascade in murine monocyte differentiation.
- Epigenetics in Sports
- Genome-Level Analysis of Selective Constraint without Apparent Sequence Conservation
- Epigenetics of reprogramming to induced pluripotency
- MYC association with cancer risk and a new model of MYC-mediated repression.
- DNA methylation as a diagnostic and therapeutic target in the battle against Type 2 diabetes.
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