Multipoint quantitative-trait linkage analysis in general pedigrees.
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Summary
It is shown how variance-component linkage methods can be used in pedigrees of arbitrary size and complexity, and a general framework for multipoint identity-by-descent (IBD) probability calculations is developed.
- Type
- article
- Published
- 1998-05-01
- Cited by
- 3,168
- References
- 43
- Access
- Open access
- OpenAlex
- https://openalex.org/W2115335486
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:14810536
Keywords
Identity by descent, Pedigree chart, Linkage (software), Quantitative trait locus, Genetic linkage
References
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- The probabilistic determination of identity-by-descent sharing for pairs of relatives from pedigrees.
- Multipoint interval mapping of quantitative trait loci, using sib pairs.
- Programs for pedigree analysis: Mendel, Fisher, and dGene
- Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results
- 1.P.281 Two major genes influence levels of unesterified cholesterol in an HDL subfraction, HDL2a
- Probability of gene identity by descent: computation and applications.
- Statistical properties of a variance components method for quantitative trait linkage analysis in nuclear families and extended pedigrees
- Multipoint oligogenic linkage analysis of quantitative traits
- A general model for the genetic analysis of pedigree data.
- Effects of genotype‐by‐sex interaction on quantitative trait linkage analysis
- Construction of multilocus genetic linkage maps in humans.
- MCMC segregation and linkage analysis
- Genetic analysis of simulated oligogenic traits in nuclear and extended pedigrees: Summary of GAW10 contributions
- Use of robust variance components models to analyse triglyceride data in families
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- Linkage analysis in the presence of errors I: complex-valued recombination fractions and complex phenotypes.
- Genome-Wide Linkage Analysis Reveals Evidence of Multiple Regions That Influence Variation in Plasma Lipid and Apolipoprotein Levels Associated With Risk of Coronary Heart Disease
- Shifting paradigms in gene-mapping methodology for complex traits.
- Coincident Linkage of Fasting Plasma Insulin and Blood Pressure to Chromosome 7q in Hypertensive Hispanic Families
- Genetic epidemiology of fecal egg excretion during Schistosoma mansoni infection in an endemic area in Minas Gerais, Brazil.
- Power of regression and maximum likelihood methods to map QTL from sib‐pair and DZ twin data
- An evaluation of the variance components approach: type I error, power and size of the estimated effect
- Genetics of asthma and atopy
- Linkage and linkage disequilibrium mapping of ERP and EEG phenotypes.
- The genetics of epilepsy in the Belgian tervuren and sheepdog.
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- High-Resolution Joint Linkage Disequilibrium and Linkage Mapping of Quantitative Trait Loci Based on Sibship Data
- Socioeconomic, Demographic, and Geographic Variables Affecting the Diverse Degrees of Consanguineous Marriages in Spain
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- Genetical genomics in humans and model organisms.
- Genomewide linkage scan for cocaine dependence and related traits: Significant linkages for a cocaine‐related trait and cocaine‐induced paranoia
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