Identifying the phenotypic effect of rare variants by including between-pedigree coancestry in variance components linkage analysis
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Summary
A method for variance-components linkage that can incorporate large number of markers and allows for between-pedigree relatedness is presented and it is shown that power is increased in the scenario when there is a haplotype shared IBD between members of different pedigrees.
- Type
- preprint
- Published
- 2017-11-07
- Cited by
- 0
- References
- 14
- Access
- Open access
- OpenAlex
- https://openalex.org/W2767506404
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:90475482
Keywords
Pedigree chart, Identity by descent, Linkage (software), Genotyping, Genetics
References
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- Robust variance-components approach for assessing genetic linkage in pedigrees.
- Construction of multilocus genetic linkage maps in humans.
- Identity by Descent Estimation With Dense Genome-Wide Genotype Data
- Cryptic Distant Relatives Are Common in Both Isolated and Cosmopolitan Genetic Samples
- Length distributions of identity by descent reveal fine-scale demographic history.
- Merlin—rapid analysis of dense genetic maps using sparse gene flow trees
- The architecture of long-range haplotypes shared within and across populations.
- Detection of sharing by descent, long-range phasing and haplotype imputation
- Multipoint quantitative-trait linkage analysis in general pedigrees.
- The Geography of Recent Genetic Ancestry across Europe
- A fast, powerful method for detecting identity by descent.
- Linkage Analysis without Defined Pedigrees
- A combined long-range phasing and long haplotype imputation method to impute phase for SNP genotypes
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