Large-scale association analyses identifies 13 new susceptibility loci for coronary artery disease
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Summary
A meta-analysis of genome-wide association studies of coronary artery disease comprising 22,233 individuals with CAD and 64,762 controls of European descent followed by genotyping of top association signals found 13 loci newly associated with CAD at P < 5 × 10−8 and confirmed the association of 10 of 12 previously reported CAD loci.
- Type
- review
- Published
- 2011-03-06
- Cited by
- 1,929
- References
- 81
- Access
- Open access
- OpenAlex
- https://openalex.org/W2112848098
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:10115843
Keywords
Biology, Coronary artery disease, Genome-wide association study, Genotyping, Genetics
References
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- A Genome-Wide Association Study Identifies Susceptibility Variants for Type 2 Diabetes in Han Chinese
- CXCL16 is a marker of inflammation, atherosclerosis, and acute coronary syndromes in humans.
Cited by
- Die Gutenberg Gesundheitsstudie
- Linking disease associations with regulatory information in the human genome
- Rare Variant Association Testing Under Low-Coverage Sequencing
- Genetics and genomics for the prevention and treatment of cardiovascular disease: update: a scientific statement from the American Heart Association.
- Apolipoprotein E Gene Polymorphism and Risk for Coronary Heart Disease in the Chinese Population: A Meta-Analysis of 61 Studies Including 6634 Cases and 6393 Controls
- Association of six genetic variants with myocardial infarction.
- Effects of Polymorphisms in APOA4-APOA5-ZNF259-BUD13 Gene Cluster on Plasma Levels of Triglycerides and Risk of Coronary Heart Disease in a Chinese Han Population
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- Clinical worthlessness of genetic prediction of common forms of diabetes mellitus and related chronic complications: A position statement of the Italian Society of Diabetology.
- A decade of genome-wide association studies for coronary artery disease: the challenges ahead
- Genetically proxied HTRA1 protease activity and circulating levels independently predict risk of ischemic stroke and coronary artery disease
- Stratégies de recherches de phénomènes d’interactions dans les maladies multifactorielles
- High intestinal cholesterol absorption is associated with cardiovascular disease and risk alleles in ABCG8 and ABO: evidence from the LURIC and YFS cohorts and from a meta-analysis.
- Genetic determinants of cardiovascular disease : heritability and genetic risk score
- Genes and coronary artery disease: where are we?
- Effect of long-term exposure to lower low-density lipoprotein cholesterol beginning early in life on the risk of coronary heart disease: a Mendelian randomization analysis.
- Chromosome 9p21.3 locus for coronary artery disease: how little we know.
- Haptoglobin, the good and the bad: is it evidence based?
- Prediction of Ischemic Events on the Basis of Transcriptomic and Genomic Profiling in Patients Undergoing Carotid Endarterectomy
- Translational studies of A20 in atherosclerosis and cardiovascular disease.
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