Effect of long-term exposure to lower low-density lipoprotein cholesterol beginning early in life on the risk of coronary heart disease: a Mendelian randomization analysis.
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Summary
Prolonged exposure to lower LDL-C beginning early in life is associated with a substantially greater reduction in the risk of CHD than the current practice of lowering cholesterol beginning later in life.
- Type
- review
- Published
- 2012-12-25
- Cited by
- 845
- References
- 48
- Access
- Open access
- OpenAlex
- https://openalex.org/W72392028
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:9411643
Keywords
Medicine, Cardiology, Internal medicine, Coronary heart disease, Term (time)
References
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- Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study
- Genetic Loci Influencing C-reactive Protein Levels and Risk of Coronary Heart Disease
- A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease
- Lowering LDL--Not Only How Low, But How Long?
- Large-Scale Gene-Centric Analysis Identifies Novel Variants for Coronary Artery Disease
- Large Scale Association Analysis of Novel Genetic Loci for Coronary Artery Disease
- PCSK9 R46L, low-density lipoprotein cholesterol levels, and risk of ischemic heart disease: 3 independent studies and meta-analyses.
- Effect of protein convertase subtilisin/kexin type 9 (PCSK9) 46L gene polymorphism on LDL cholesterol concentration in a Polish adult population.
- Joint Effects of Common Genetic Variants from Multiple Genes and Pathways On the Risk of Premature Coronary Artery Disease
- Lifelong Reduction of LDL-Cholesterol Related to a Common Variant in the LDL-Receptor Gene Decreases the Risk of Coronary Artery Disease—A Mendelian Randomisation Study
- A Common KIF6 Polymorphism Increases Vulnerability to Low-Density Lipoprotein Cholesterol: Two Meta-Analyses and a Meta-Regression Analysis
- Genetic variation at the PCSK9 locus moderately lowers low-density lipoprotein cholesterol levels, but does not significantly lower vascular disease risk in an elderly population.
- Forty-Three Loci Associated with Plasma Lipoprotein Size, Concentration, and Cholesterol Content in Genome-Wide Analysis
- Genome-wide association of early-onset myocardial infarction with common single nucleotide polymorphisms, common copy number variants, and rare copy number variants
- Can we dramatically reduce the incidence of coronary heart disease?
- Sequence variations in PCSK9, low LDL, and protection against coronary heart disease.
- Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
- A PCSK9 missense variant associated with a reduced risk of early-onset myocardial infarction.
- Genetic Variants in Novel Pathways Influence Blood Pressure and Cardiovascular Disease Risk
Cited by
- The case for treating hypercholesterolemia at an earlier age: moving toward consensus.
- Update Fettstoffwechselstörungen
- Brotherhood of genetics and preventive medication.
- Insight into rheumatological cause and effect through the use of Mendelian randomization
- Progress and perspectives in plant sterol and plant stanol research
- How do statins work?: changing paradigms with implications for statin allocation.
- Effect of Naturally Random Allocation to Lower Low-Density Lipoprotein Cholesterol on the Risk of Coronary Heart Disease Mediated by Polymorphisms in NPC1L1, HMGCR, or Both
- Japan Atherosclerosis Society (JAS) Guidelines for Prevention of Atherosclerotic Cardiovascular Diseases 2017
- A Healthy Nordic Diet and Cardiometabolic Risk Factors : Intervention Studies with Special Emphasis on Plasma Lipoproteins
- Dyslipidemia in rat fed with high-fat diet is not associated with PCSK9-LDL-receptor pathway but ageing
- Pediatric Lipid Management
- Mendelian Randomization versus Path Models: Making Causal Inferences in Genetic Epidemiology
- Beyond Mendelian randomization: how to interpret evidence of shared genetic predictors
- Reply: Genetic Variation in NPC1L1 and Risk of Gallstone Disease.
- New AHA and ACC guidelines on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular risk
- An ecologically valid assessment of the 'exercise is medicine' hypothesis
- Serum cholesterol as a risk factor for coronary heart disease revisited
- Novel lipid derivatives for health benefits
- Temporal Trends in Lipid Screening and Therapy Among Youth from 2002–2012
- National Lipid Association Recommendations for Patient-Centered Management of Dyslipidemia: Part 2.
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