Genes and coronary artery disease: where are we?
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Summary
While risk variants are less potent predictors of CAD, compared with biomarkers, they have the advantage of not changing in one's lifetime and are unaffected by diet, sex, age, or medication.
- Type
- review
- Published
- 2012-10-30
- Cited by
- 172
- References
- 58
- Access
- Open access
- OpenAlex
- https://openalex.org/W65279318
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:9037363
Keywords
Genome-wide association study, Medicine, Coronary artery disease, Odds ratio, Single-nucleotide polymorphism
References
- Recommendations from the EGAPP Working Group: Genomic profiling to assess cardiovascular risk to improve cardiovascular health
- Polymorphism on chromosome 9p21.3 contributes to early-onset and severity of coronary artery disease in non-diabetic and type 2 diabetic patients.
- A Common Variant in the CDKN2B Gene on Chromosome 9p21 Protects Against Coronary Artery Disease in Americans of African Ancestry
- A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium
- A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease
- A Common Allele on Chromosome 9 Associated with Coronary Heart Disease
- Targeted Deletion of the 9p21 Noncoding Coronary Artery Disease Risk Interval in Mice
- Large-Scale Gene-Centric Analysis Identifies Novel Variants for Coronary Artery Disease
- Six sequence variants on chromosome 9p21.3 are associated with a positive family history of myocardial infarction: a multicenter registry
- Gene-Environment Interactions and Gene Therapy in Atherosclerosis
- The same sequence variant on 9p21 associates with myocardial infarction, abdominal aortic aneurysm and intracranial aneurysm
- Influence of 9p21.3 genetic variants on clinical and angiographic outcomes in early-onset myocardial infarction.
- Genetic variation at the 9p21 locus predicts angiographic coronary artery disease prevalence but not extent and has clinical utility.
- A common variant on chromosome 9p21 affects the risk of myocardial infarction.
- 9p21 DNA variants associated with Coronary Artery Disease impair IFNγ signaling response
- The Association Between Variants on Chromosome 9p21 and Inflammatory Biomarkers in Ethnically Diverse Women With Coronary Heart Disease: A Pilot Study
- A common variant on chromosome 9p21 affects the risk of early-onset coronary artery disease
- Gene dosage of the common variant 9p21 predicts severity of coronary artery disease.
- Association between 9p21 genomic markers and heart disease: a meta-analysis.
- Chromosome 9p21 SNPs Associated with Multiple Disease Phenotypes Correlate with ANRIL Expression
Cited by
- Association between the MARS rs6782181 polymorphism and serum lipid levels.
- A Detailed Family History of Myocardial Infarction and Risk of Myocardial Infarction – A Nationwide Cohort Study
- Single-nucleotide polymorphisms at the 9p21.3 genomic region not associated with the risk of cardiovascular disease in patients with rheumatoid arthritis.
- Association Between Genetic Variation in the SCN10A Gene and Cardiac Conduction Abnormalities in Patients With Hypertrophic Cardiomyopathy.
- Applying Supervised Learning Algorithms and a New Feature Selection Method to Predict Coronary Artery Disease
- β‐Estradiol results in a proprotein convertase subtilisin/kexin type 9‐dependent increase in low‐density lipoprotein receptor levels in human hepatic HuH7 cells
- Molecular genetics of coronary artery disease
- A genomewide study of body mass index and its genetic correlation with thromboembolic risk
- Potential Signals of Natural Selection in the Top Risk Loci for Coronary Artery Disease: 9p21 and 10q11
- Immigration, myocardial infarction, and type 1 diabetes in Sweden : use of the migration and health cohort
- Genomics in Cardiovascular Disease
- Prescribing Personalized Nutrition for Cardiovascular Health: Are We Ready?
- Haplotype analyses of CYP17A1 genetic polymorphisms and coronary artery disease in a Uygur population
- Association of the AGXT2 V140I polymorphism with risk for coronary heart disease in a Chinese population.
- Fine tuning of proteomic technologies to improve biological findings: advancements in 2011-2013.
- Association of miR-146a rs2910164 polymorphism with cardio-cerebrovascular diseases: A systematic review and meta-analysis.
- Coronary artery disease in Bangladesh: a review.
- Plasma PCSK9 Levels Are Elevated with Acute Myocardial Infarction in Two Independent Retrospective Angiographic Studies
- Functional Genomics of the 9p21.3 Locus for Atherosclerosis: Clarity or Confusion?
- Why did ancient people have atherosclerosis?: from autopsies to computed tomography to potential causes.
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