Mitochondrial targeting of tBid/Bax: a role for the TOM complex?
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Summary
Recent work on the mechanisms of activation and the targeting of Bax to the mitochondria are reviewed and the advantages and limitations of the methods used to study this process are discussed.
- Type
- review
- Published
- 2009-06-12
- Cited by
- 98
- References
- 52
- Access
- Open access
- OpenAlex
- https://openalex.org/W2062602336
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:11322867
Keywords
Intermembrane space, Translocase of the outer membrane, Mitochondrial intermembrane space, Cell biology, Cardiolipin
References
- Structure of Bax: coregulation of dimer formation and intracellular localization.
- Calcium: Regulation of cell death: the calcium–apoptosis link
- Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC
- Bad targets the permeability transition pore independent of Bax or Bak to switch between Ca2+-dependent cell survival and death
- The Mitochondrial TOM Complex Is Required for tBid/Bax-induced Cytochrome c Release*
- An Essential Role of Sam50 in the Protein Sorting and Assembly Machinery of the Mitochondrial Outer Membrane*
- The BCL-2 protein family: opposing activities that mediate cell death
- Structure-Function Analysis of Bcl-2 Protein
- TOM22, a core component of the mitochondria outer membrane protein translocation pore, is a mitochondrial receptor for the proapoptotic protein Bax
- Cardiolipin deficiency releases cytochrome c from the inner mitochondrial membrane and accelerates stimuli-elicited apoptosis
- Signal-anchored Proteins Follow a Unique Insertion Pathway into the Outer Membrane of Mitochondria*
- VDAC2 Inhibits BAK Activation and Mitochondrial Apoptosis
- TOM-independent complex formation of Bax and Bak in mammalian mitochondria during TNFα-induced apoptosis
- Bak regulates mitochondrial morphology and pathology during apoptosis by interacting with mitofusins
- Targeting and tracing antigens in live cells with fluorescent nanobodies
- Hierarchical regulation of mitochondrion-dependent apoptosis by BCL-2 subfamilies
- Apoptosis Initiated When BH3 Ligands Engage Multiple Bcl-2 Homologs, Not Bax or Bak
- How does the TOM complex mediate insertion of precursor proteins into the mitochondrial outer membrane?
- Lipid analysis of mitochondrial membranes from the yeast Pichia pastoris.
- Pro-apoptotic cascade activates BID, which oligomerizes BAK or BAX into pores that result in the release of cytochrome c
Cited by
- Where killers meet--permeabilization of the outer mitochondrial membrane during apoptosis.
- TOM7 silencing exacerbates focal cerebral ischemia injury in rat by targeting PINK1/Beclin1‐mediated autophagy
- The mitochondrial pathways of apoptosis.
- Phyto mediated biogenic synthesis of silver nanoparticles using leaf extract of Andrographis echioides and its bio-efficacy on anticancer and antibacterial activities.
- Proteomic analysis of cellular models of neurodegeneration and mitochondrial dysfunction
- Intimacy and a deadly feud: the interplay of autophagy and apoptosis mediated by amino acids
- Impact de la protéine CHMP2B et de ses variants pathogènes sur le modelage des membranes biologiques
- Interaction of the alpha‐helical H6 peptide from the pro‐apoptotic protein tBid with cardiolipin
- Mitochondrial involvement in cell death: release of pro-apoptotic proteins
- Induction of Apoptosis by Ethanolic Extract of Corchorus olitorius Leaf in Human Hepatocellular Carcinoma (HepG2) Cells via a Mitochondria-Dependent Pathway
- Piperonal ciprofloxacin hydrazone induces growth arrest and apoptosis of human hepatocarcinoma SMMC-7721 cells
- Sulfuretin from heartwood of Rhus verniciflua triggers apoptosis through activation of Fas, Caspase‐8, and the mitochondrial death pathway in HL‐60 human leukemia cells
- Expressing and functional analysis of mammalian apoptotic regulators in yeast
- Inductive effect of phytoglycoprotein (38 kDa) on G0/G1 arrest and apoptosis in diethylnitrosamine-treated ICR mice
- Regulation of mitochondrial nutrient and energy metabolism by BCL-2 family proteins
- Function of cytosolic chaperones in Tom70-mediated mitochondrial import.
- Metaxins 1 and 2, two proteins of the mitochondrial protein sorting and assembly machinery, are essential for Bak activation during TNF alpha triggered apoptosis.
- Expression of the Bcl-2 family genes and complexes involved in the mitochondrial transport in prostate cancer cells.
- Role of apoptosis-inducing factor, proline dehydrogenase, and NADPH oxidase in apoptosis and oxidative stress
- Bid and Bax are involved in granulosa cell apoptosis during follicular atresia in porcine ovaries.
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