Mitochondria as functional targets of proteins coded by human tumor viruses.
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Summary
Experimental evidence indicates that the viral BCL-2 homologues BHRF1 and KSBCL-2 inhibit apoptosis triggered by a variety of stimuli and could aid in the discovery of new targets for anti-tumor therapy.
- Type
- article
- Published
- 2005-01-01
- Cited by
- 62
- References
- 289
- OpenAlex
- https://openalex.org/W16096000
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:21339944
Keywords
Poverty, Culture of poverty, Context (archaeology), Empowerment, Variety (cybernetics)
References
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- A conserved basic loop in hepatitis C virus p7 protein is required for amantadine-sensitive ion channel activity in mammalian cells but is dispensable for localization to mitochondria.
- Bik, a novel death-inducing protein shares a distinct sequence motif with Bcl-2 family proteins and interacts with viral and cellular survival-promoting proteins.
- The Epstein-Barr virus gene BHRF1, a homologue of the cellular oncogene Bcl-2, inhibits apoptosis induced by gamma radiation and chemotherapeutic drugs.
- Epidemiology of Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8.
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- BHRF1, a viral homologue of the Bcl-2 oncogene, disturbs epithelial cell differentiation.
- Hepatitis C Viruses
- The human immunodeficiency virus type 1 vpr gene arrests infected T cells in the G2 + M phase of the cell cycle
- A novel influenza A virus mitochondrial protein that induces cell death
- The apoptotic v-cyclin–CDK6 complex phosphorylates and inactivates Bcl-2
- Cyclosporin and carnitine prevent the anoxic death of cultured hepatocytes by inhibiting the mitochondrial permeability transition.
- An APAF-1·Cytochrome c Multimeric Complex Is a Functional Apoptosome That Activates Procaspase-9*
- Human herpesvirus-8 and Kaposi's sarcoma: relationship with the multistep concept of tumorigenesis.
Cited by
- Mitochondrial Proteins Coded by Human Tumor Viruses
- Functional characterization of the p13 protein of HTLV-1
- Effects of Hepatitis C core protein on mitochondrial electron transport and production of reactive oxygen species
- Cancer as a mitochondrial metabolic disease
- A calcium-based theory of carcinogenesis.
- Viroporins, Examples of the Two-Stage Membrane Protein Folding Model
- INTERAÇÃO DE ONCOPROTEÍNAS VIRAIS E6 E E7 DE HPV16/18 COM ALVOS CELULARES POTENCIAIS PARA O DESENVOLVIMENTO DE ESTRATÉGIAS TERAPÊUTICAS
- Intertwined pathways of programmed cell death in immunity
- Mitochondrial membrane permeabilization in cell death.
- Biophysical and biochemical models of mechanisms of cellular development via the cellular cycle in normal tissue, cancerous tissue, and inflammatory processes.
- Targeted Vpr-derived peptides reach mitochondria to induce apoptosis of αVβ3-expressing endothelial cells
- Pathological Survivin Expression Links Viral Infections with Pathogenesis of Erosive Rheumatoid Arthritis
- HTLV-1 and HTLV-2: highly similar viruses with distinct oncogenic properties
- Subcellular localizations of the hepatitis C virus alternate reading frame proteins.
- Functional implications of mitochondrial reactive oxygen species generated by oncogenic viruses
- Discovery and significance of new human T-lymphotropic viruses: HTLV-3 and HTLV-4
- A flavivirus protein M-derived peptide directly permeabilizes mitochondrial membranes, triggers cell death and reduces human tumor growth in nude mice
- Comparison of the Genetic Organization, Expression Strategies and Oncogenic Potential of HTLV-1 and HTLV-2
- Viroporins from RNA viruses induce caspase‐dependent apoptosis
- Immunopathogenesis Versus Protection in Dengue Virus Infections
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