Sequence diversity in CYP3A promoters and characterization of the genetic basis of polymorphic CYP3A5 expression

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Summary

CYP3A5 was more frequently expressed in livers of African Americans than in those of Caucasians, and may be the most important genetic contributor to interindividual and interracial differences in CYP3A-dependent drug clearance and in responses to many medicines.

Type
article
Published
2001-04-01
Cited by
2,266
References
48
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Keywords

Biology, CYP3A5, CYP3A, Single-nucleotide polymorphism, Genetics

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