Sequence diversity in CYP3A promoters and characterization of the genetic basis of polymorphic CYP3A5 expression
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Summary
CYP3A5 was more frequently expressed in livers of African Americans than in those of Caucasians, and may be the most important genetic contributor to interindividual and interracial differences in CYP3A-dependent drug clearance and in responses to many medicines.
- Type
- article
- Published
- 2001-04-01
- Cited by
- 2,266
- References
- 48
- Access
- Open access
- OpenAlex
- https://openalex.org/W2105902511
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:1133371
Keywords
Biology, CYP3A5, CYP3A, Single-nucleotide polymorphism, Genetics
References
- Expression of cytochrome P450 3A in amphibian, rat, and human kidney.
- Characterization of single-nucleotide polymorphisms in coding regions of human genes
- Two linked mutations in transcriptional regulatory elements of the CYP3A5 gene constitute the major genetic determinant of polymorphic activity in humans.
- Cytochrome P-450 hPCN3, a novel cytochrome P-450 IIIA gene product that is differentially expressed in adult human liver. cDNA and deduced amino acid sequence and distinct specificities of cDNA-expressed hPCN1 and hPCN3 for the metabolism of steroid hormones and cyclosporine.
- The power of point mutations
- Modulators and substrates of P-glycoprotein and cytochrome P4503A coordinately up-regulate these proteins in human colon carcinoma cells.
- Corticosterone 6 beta-hydroxylase in A6 epithelia: a steroid-inducible cytochrome P-450.
- Studies on the expression and metabolic capabilities of human liver cytochrome P450IIIA5 (HLp3).
- Identification of a polymorphically expressed member of the human cytochrome P-450III family.
- When cells stop making sense: effects of nonsense codons on RNA metabolism in vertebrate cells.
- Characterization of interintestinal and intraintestinal variations in human CYP3A-dependent metabolism.
- Gene structure of CYP3A4, an adult-specific form of cytochrome P450 in human livers, and its transcriptional control.
- Population distribution and effects on drug metabolism of a genetic variant in the 5′ promotor region of CYP3A4
- The human cytochrome P450 3A locus. Gene evolution by capture of downstream exons.
- PolyPhred: automating the detection and genotyping of single nucleotide substitutions using fluorescence-based resequencing.
- Regioselective biotransformation of midazolam by members of the human cytochrome P450 3A (CYP3A) subfamily.
- Selective expression of cytochrome P450 CYP3A mRNAs in embryonic and adult human liver.
- Characterization of a cDNA encoding a new member of the glucocorticoid-responsive cytochromes P450 in human liver.
- The role of individual human cytochromes P450 in drug metabolism and clinical response.
- Pharmacogenomics: translating functional genomics into rational therapeutics.
Cited by
- Impact of CYP3A5 genotype of recipients as well as donors on the tacrolimus pharmacokinetics and infectious complications after living-donor liver transplantation for Japanese adult recipients.
- Mutation analysis of the human CYP3A4 gene 5' regulatory region: population screening using non-radioactive SSCP.
- Pharmacokinetics of midazolam in CYP3A4- and CYP3A5-genotyped subjects
- The Induction of Cytochrome P450 3A5 (CYP3A5) in the Human Liver and Intestine Is Mediated by the Xenobiotic Sensors Pregnane X Receptor (PXR) and Constitutively Activated Receptor (CAR)*
- Activity of cytochrome P450 in children
- Predicting drug response and toxicity based on gene polymorphisms.
- Pharmacokinetic Considerations Relating to Tacrolimus Dosing in the Elderly
- Update on pharmacogenetics in epilepsy: a brief review.
- Genetic polymorphism of cytochrome P450s and P‐glycoprotein in the Finnish population
- Comparison of basal gene expression and induction of CYP3As in HepG2 and human fetal liver cells.
- Overview of Pharmacogenetics
- CYP3A5 polymorphism and sensitivity of blood pressure to dietary salt in Japanese men
- Developmental pharmacokinetics of etoposide in 67 children: lack of dexamethasone effect
- Potent inhibition of human cytochrome P450 3A isoforms by cannabidiol: role of phenolic hydroxyl groups in the resorcinol moiety.
- Association Between CYP3A5 Polymorphisms and Blood Pressure in Kidney Transplant Recipients Receiving Calcineurin Inhibitors
- Triazole antifungal agents drug–drug interactions involving hepatic cytochrome P450
- Impact of CYP3A5 genetic polymorphism on cross-reactivity in tacrolimus chemiluminescent immunoassay in kidney transplant recipients.
- Effect of CYP3A51/3 polymorphism on blood pressure in renal transplant recipients.
- CYP3A4*22: promising newly identified CYP3A4 variant allele for personalizing pharmacotherapy.
- Pharmacogenetics in solid organ transplantation: genes involved in mechanism of action and pharmacokinetics of immunosuppressive drugs.
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