Modulators and substrates of P-glycoprotein and cytochrome P4503A coordinately up-regulate these proteins in human colon carcinoma cells.
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Summary
The apparent coordinated coexpression of the CYP3A gene family and P-glycoprotein in the LS180 cells suggests that for common orally administered drugs, P- glycoprotein may play an important role in net drug absorption and drug/drug interactions of shared CYP 3A4/P-gly Coprotein substrates.
- Type
- article
- Published
- 1996-02-01
- Cited by
- 533
- References
- 0
- OpenAlex
- https://openalex.org/W1787076927
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:35132709
Keywords
CYP3A4, CYP3A, P-glycoprotein, Pregnane X receptor, Efflux
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