The human cytochrome P450 3A locus. Gene evolution by capture of downstream exons.

Keywords

Biology, Pseudogene, Exon, CYP3A, Genetics

References

• Expression of cytochrome P450 3A in amphibian, rat, and human kidney.Massimo Pennesi — 1992
• Expression of CYP3A4, CYP3A5 and CYP3A7 in human duodenal tissue.Juan Carlos Prado — 2003
• ISIS, the intron information system, reveals the high frequency of alternative splicing in the human genomeLarry Croft, Soeren Schandorff, Francis Clark — 2000
• The gene CYP3 encoding P450pcn1 (nifedipine oxidase) is tightly linked to the gene COL1A2 encoding collagen type 1 alpha on 7q21-q22.1.B.A. Brooks, O W McBride, Colin T. Dolphin — 1988
• Selective sweep of a newly evolved sperm-specific gene in DrosophilaDmitry I. Nurminsky, Maria V. Nurminskaya, Daniel De Aguiar — 1998
• Identification of a novel dexamethasone responsive enhancer in the human CYP3A5 gene and its activation in human and rat liver cells.John D. Schuetz, Erin G. Schuetz, Jaideep V. Thottassery — 1996
• Gene structure of CYP3A4, an adult-specific form of cytochrome P450 in human livers, and its transcriptional control.Hisashi Hashimoto, Kenji TOIDE, Ryuji Kitamura — 1993
• Sequence of the 5'-flanking region of CYP3A5: comparative analysis with CYP3A4 and CYP3A7.Youssef Jounaïdi, Philip S. Guzelian, Patrick Maurel — 1994
• Isolation of CYP3A5P cDNA from human liver: a reflection of a novel cytochrome P-450 pseudogene.John D. Schuetz, Philip S. Guzelian — 1995
• The INK4A/ARF locus and its two gene products.Norman E. Sharpless, Ronald A. DePinho — 1999
• P450 superfamily: update on new sequences, gene mapping, accession numbers and nomenclature.David R. Nelson, Luc Koymans, Tetsuya Kamataki — 1996
• Why genes in pieces?Walter Gilbert — 1978
• RNAs from all categories generate retrosequences that may be exapted as novel genes or regulatory elements.J. Brosius — 1999
• Natural selection and the origin of jingwei, a chimeric processed functional gene in Drosophila.Manyuan Long, Charles H. Langley — 1993
• Orthologs, paralogs and genome comparisons.J. Peter Gogarten, Lorraine Olendzenski — 1999
• The human CYP2C locus: a prototype for intergenic and exon repetition splicing events.Csaba Finta, Peter G. Zaphiropoulos — 2000
• Back to the roots of a new exon--the molecular archaeology of a SP100 splice variant.Piere Rogalla, Bernd Kazmierczak, Aljoscha M. Flohr — 2000
• cDNA cloning and initial characterization of CYP3A43, a novel human cytochrome P450.Tammy L. Domanski, Csaba Finta, James R. Halpert — 2001
• Retroposition of autosomal mRNA yielded testis-specific gene family on human Y chromosomeBruce T. Lahn, David C. Page — 1999
• Cytochrome P-450 3A4: regulation and role in drug metabolism.F. Peter Guengerich — 1999

Cited by

• The Induction of Cytochrome P450 3A5 (CYP3A5) in the Human Liver and Intestine Is Mediated by the Xenobiotic Sensors Pregnane X Receptor (PXR) and Constitutively Activated Receptor (CAR)*Robert Ashby — 2004
• Overview of PharmacogeneticsDavid A. Katz — 2006
• In vitro screening of cytochrome P450 induction potential.Olavi Pelkonen, Janne Hukkanen, Paavo Honkakoski — 2002
• Differential Induction of Drug Metabolizing Enzymes and Drug Transporters by Tamoxifen: Molecular Mechanisms and Clinical ImplicationsRucha Sane — 2006
• Genetics and Philosophy: An IntroductionP. Griffiths, K. Stotz — 2013
• Cytochrome P450: another player in the myocardial infarction game?Raute Sunder‐Plaßmann — 2007
• A Roadmap to Individualized Irinotecan DosingF. D. Jong — 2006
• Phylogenetic Inference for Multidomain ProteinsMaureen Stolzer — 2011
• The role of genetic factors in determining the clinical efficacy of clopidogrel.R. Tzveova, A. Mitkova, I. Paskaleva — 2013
• Variabilité pharmacocinétique de la névirapine et de l’éfavirenz et rôle du polymorphisme des enzymes et transporteurs dans une population de patients cambodgiens infectés par le VIH et traités par une association d’antirétroviraux comprenant névirapine ou éfavirenzMonidarin Chou — 2011
• Molecular docking of chemotherapeutic agents to CYP3A4 in non-small cell lung cancer.Syed Subhani, Kaiser Jamil — 2015
• Genetic factors for individual administration of immunosuppressants in organ transplantation.Songfeng Yu, Lihua Wu, Shusen Zheng — 2006
• Islands of linkage disequilibriumDavid B. Goldstein — 2001
• ChimerDB - Database of Chimeric Sequences in the GenBankNamshin Kim, Shin Seokmin, Cho Kwang-Hwi — 2004
• Metabolic and mechanistic exploration of a novel programmable genotoxicant against prostate cancerC. Morton — 2009
• 906 variations among 27 genes encoding cytochrome P450 (CYP) enzymes and aldehyde dehydrogenases (ALDHs) in the Japanese populationSusumu Saito, Aritoshi Iida, Akihiro Sekine — 2002
• Transcriptional control of intestinal cytochrome P-4503A by 1alpha,25-dihydroxy vitamin D3.Kenneth E. Thummel, Cynthia Brimer, Kazuto Yasuda — 2001
• Genetic polymorphism of cytochrome P450 3A5 in Chinese.Frank Chou, Shih-Hao Tzeng, Jin‐ding Huang — 2001
• A Map of the Mouse Cyp3a LocusPeter G. Zaphiropoulos — 2003
• Genetic polymorphisms of drug‐metabolizing phase I enzymes CYP2E1, CYP2A6 and CYP3A5 in South Indian populationD. Krishnakumar, Gurusamy Umamaheswaran, Kayathri Dhandapani — 2012

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