Two linked mutations in transcriptional regulatory elements of the CYP3A5 gene constitute the major genetic determinant of polymorphic activity in humans.

Keywords

Biology, Genetics, CYP3A, CYP3A5, Gene

References

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• Use of tacrolimus in Chinese renal transplant recipientsChi Yuen Cheung — 2009
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• Pharmacogenetics and cancer therapyMary V. Relling, Thierry Dervieux — 2001
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