The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1
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Summary
The findings indicate that the pathological process associated with p62 accumulation results in hyperactivation of Nrf2 and delineates unexpected roles of selective autophagy in controlling the transcription of cellular defence enzyme genes.
- Type
- article
- Published
- 2010-03-01
- Cited by
- 2,373
- References
- 53
- OpenAlex
- https://openalex.org/W2102354517
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:31148149
Keywords
KEAP1, Autophagy, Transcription factor, Ubiquitin ligase, Cell biology
References
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- The PyMOL Molecular Graphics System
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- Autophagy Inhibition Compromises Degradation of Ubiquitin-Proteasome Pathway Substrates
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- Unveiling the roles of autophagy in innate and adaptive immunity
- Loss of autophagy diminishes pancreatic beta cell mass and function with resultant hyperglycemia.
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Cited by
- Role of the Keap1-Nrf2 pathway in cancer.
- p62, an autophagy hero or culprit?
- A Noncanonical Mechanism of Nrf2 Activation by Autophagy Deficiency: Direct Interaction between Keap1 and p62
- p62/SQSTM1/A170: physiology and pathology.
- A novel small molecule, N-(4-(2-pyridyl)(1,3-thiazol-2-yl))-2-(2,4,6-trimethylphenoxy) acetamide, selectively protects against oxidative stress-induced cell death by activating the Nrf2-ARE pathway: therapeutic implications for ALS.
- Autophagy Paradox and Ceramide
- Livers with Constitutive mTORC1 Activity Resist Steatosis Independent of Feedback Suppression of Akt
- Identifying panaxynol, a natural activator of nuclear factor erythroid-2 related factor 2 (Nrf2) from American ginseng as a suppressor of inflamed macrophage-induced cardiomyocyte hypertrophy
- Characterization of RA839, a Noncovalent Small Molecule Binder to Keap1 and Selective Activator of Nrf2 Signaling*
- Elevated p62/SQSTM1 determines the fate of autophagy-deficient neural stem cells by increasing superoxide
- Nrf2 Activation Inhibits Effects of Thrombin in Human Amnion Cells and Thrombin-Induced Preterm Birth in Mice.
- Low-Dose Irradiation Promotes Persistent Oxidative Stress and Decreases Self-Renewal in Hematopoietic Stem Cells.
- HSV-TK/GCV can induce cytotoxicity of retinoblastoma cells through autophagy inhibition by activating MAPK/ERK
- Diverse Functions of Autophagy in Liver Physiology and Liver Diseases
- The Autophagy Lysosomal Pathway and Neurodegeneration
- DJ-1 Deficiency Protects against Sepsis-Induced Myocardial Depression
- Advances in Mechanisms of Anti-oxidation
- Etude de la modulation de la réponse cellulaire au stress oxydatif par les protéines VP24 des virus Marburg et Ebola
- Post-Transcriptional Regulation of Nrf2: Novel Mechanisms beyond Keap1
- The Effects of GMS Immunity-Related GTPases on Guanylate-Binding Proteins, Protein Aggregate Formation, and Macroautophagy
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