An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements.
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Summary
It is demonstrated that Nrf2 is essential for the transcriptional induction of phase II enzymes and the presence of a coordinate transcriptional regulatory mechanism for phase II enzyme genes and the nrf2-deficient mice may prove to be a very useful model for the in vivo analysis of chemical carcinogenesis and resistance to anti-cancer drugs.
- Type
- article
- Published
- 1997-07-18
- Cited by
- 4,004
- References
- 48
- OpenAlex
- https://openalex.org/W1991631628
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:13620263
Keywords
Transcription factor, Enzyme, Enzyme inducer, Biology, Gene
References
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- The ubiquitous subunit of erythroid transcription factor NF-E2 is a small basic-leucine zipper protein related to the v-maf oncogene.
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Cited by
- Role of the Keap1-Nrf2 pathway in cancer.
- Erythroid maturation and globin gene expression in mice with combined deficiency of NF-E2 and nrf-2.
- Phosphorylation of Nrf2 at Ser-40 by Protein Kinase C Regulates Antioxidant Response Element-mediated Transcription*
- The story so far: Molecular regulation of the heme oxygenase-1 gene in renal injury.
- Response of the brain to oligemia: gene expression, c-Fos, and Nrf2 localization.
- Chemoprevention by isothiocyanates and their underlying molecular signaling mechanisms.
- Induction of phase I, II and III drug metabolism/transport by xenobiotics
- Dietary artepillin C suppresses the formation of aberrant crypt foci induced by azoxymethane in mouse colon.
- Nrf2 Defends the Lung from Oxidative Stress
- Small Maf proteins in mammalian gene control: mere dimerization partners or dynamic transcriptional regulators?
- Polymeric black tea polyphenols induce phase II enzymes via Nrf2 in mouse liver and lungs.
- The Nrf2-Antioxidant Response Element Signaling Pathway and Its Activation by Oxidative Stress*
- Effects of atmospheric pollutants on the Nrf2 survival pathway
- The Nrf2-ARE cytoprotective pathway in astrocytes
- Targeting the Nrf2 pathway against cardiovascular disease
- Essential role of Nrf2 in keratinocyte protection from UVA by quercetin.
- Chemical inducers of heat shock proteins derived from medicinal plants and cytoprotective genes response
- Identification of novel NRF2-regulated genes by ChIP-Seq: influence on retinoid X receptor alpha
- A novel small molecule, N-(4-(2-pyridyl)(1,3-thiazol-2-yl))-2-(2,4,6-trimethylphenoxy) acetamide, selectively protects against oxidative stress-induced cell death by activating the Nrf2-ARE pathway: therapeutic implications for ALS.
- Expression of target genes of nuclear factor E2-related factor 2 in the liver of dairy cows in the transition period and at different stages of lactation.
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