Loss of autophagy diminishes pancreatic beta cell mass and function with resultant hyperglycemia.
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Summary
It is suggested that autophagy is necessary to maintain structure, mass and function of pancreatic beta cells, and its impairment causes insulin deficiency and hyperglycemia because of abnormal turnover andfunction of cellular organelles.
- Type
- article
- Published
- 2008-10-08
- Cited by
- 666
- References
- 42
- Access
- Open access
- OpenAlex
- https://openalex.org/W2022570265
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:33853793
Keywords
Autophagy, Function (biology), Pancreatic function, Cell biology, Endocrinology
References
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- p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death
- The energy sensing LKB1–AMPK pathway regulates p27kip1 phosphorylation mediating the decision to enter autophagy or apoptosis
- Mitochondrial glutamate acts as a messenger in glucose-induced insulin exocytosis
- PERK EIF2AK3 control of pancreatic beta cell differentiation and proliferation is required for postnatal glucose homeostasis.
- Growth factor regulation of autophagy and cell survival in the absence of apoptosis.
- NF-kappa B prevents beta cell death and autoimmune diabetes in NOD mice.
- ER-Phagy: Selective Autophagy of the Endoplasmic Reticulum
- Endoplasmic Reticulum Stress Triggers Autophagy*
- From acute ER stress to physiological roles of the Unfolded Protein Response
- Apoptosis of pancreatic β‐cells detected in accelerated diabetes of NOD mice: no role of Fas‐Fas ligand interaction in autoimmune diabetes
- Phosphorylation of Ribosomal Protein S6 Is Inhibitory for Autophagy in Isolated Rat Hepatocytes (*)
- Self-eating and self-killing: crosstalk between autophagy and apoptosis
- Loss of autophagy in the central nervous system causes neurodegeneration in mice
- Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetes.
- The role of autophagy in cardiomyocytes in the basal state and in response to hemodynamic stress
- Chemical Chaperones Reduce ER Stress and Restore Glucose Homeostasis in a Mouse Model of Type 2 Diabetes
- The balance between proinsulin biosynthesis and insulin secretion: where can imbalance lead?
- Autophagy gene-dependent clearance of apoptotic cells during embryonic development.
- Endoplasmic reticulum stress contributes to beta cell apoptosis in type 2 diabetes
Cited by
- Rôle du stress du réticulum endoplasmique et de l’autophagie dans la régulation des réponses immune et angiogénique activées par des stress ischémiques et inflammatoires dans l’épithélium rénal humain
- Establishment and Characterization of a Transgenic Mouse Model for In Vivo Imaging of Bmp4 Expression in the Pancreas
- Impaired proteostasis: role in the pathogenesis of diabetes mellitus
- Effect of mitochondrial stress on systemic metabolism
- Autophagy deficiency in myeloid cells increases susceptibility to obesity-induced diabetes and experimental colitis
- Streptozotocin-Induced Autophagy Reduces Intracellular Insulin in Insulinoma INS-1E Cells
- The Role of Autophagy and IL-17 in Bone Resorption
- Role of the mammalian target of rapamycin (mTOR) complexes in pancreatic β-cell mass regulation.
- Mitochondrial form and function in pancreatic β-cells and brown adipocytes
- Liraglutide prevents high glucose level induced insulinoma cells apoptosis by targeting autophagy.
- Role of crystallins in diabetic complications.
- Targeting Autophagy in the Tumor Stroma to Eradicate Breast Cancer
- Autophagy regulates hyperoxia-induced intracellular accumulation of surfactant protein C in alveolar type II cells
- Autophagy Protects against Colitis by the Maintenance of Normal Gut Microflora and Secretion of Mucus*
- AMPK and autophagy in glucose/glycogen metabolism.
- Autophagy in pancreatic cancer pathogenesis and treatment.
- Dissection du rôle de la voie intracellulaire de mTORC1 dans les circuits hypothalamiques à la mélanocortine régulant la prise alimentaire
- Autophagy and pancreatic β-cells.
- Mitochondrial metabolism and diabetes
- p53 and the role of autophagy in pancreatic cancer development
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