Loss of autophagy diminishes pancreatic beta cell mass and function with resultant hyperglycemia.

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Summary

It is suggested that autophagy is necessary to maintain structure, mass and function of pancreatic beta cells, and its impairment causes insulin deficiency and hyperglycemia because of abnormal turnover andfunction of cellular organelles.

Type
article
Published
2008-10-08
Cited by
666
References
42
Access
Open access

Keywords

Autophagy, Function (biology), Pancreatic function, Cell biology, Endocrinology

References

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