Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project
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Summary
Functional data from multiple, diverse experiments performed on a targeted 1% of the human genome as part of the pilot phase of the ENCODE Project are reported, providing convincing evidence that the genome is pervasively transcribed, such that the majority of its bases can be found in primary transcripts.
- Type
- article
- Published
- 2007-06-01
- Cited by
- 5,385
- References
- 257
- Access
- Open access
- OpenAlex
- https://openalex.org/W2102304447
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:4399576
Keywords
ENCODE, Genome, Human genome, Computational biology, Biology
References
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- Evolutionary dynamics of the enhancer region of even-skipped in Drosophila.
- Statistical significance for genomewide studies
- CAGE: cap analysis of gene expression
- A bivalent chromatin structure marks key developmental genes in embryonic stem cells.
- DNA microarrays for comparative genomic hybridization based on DOP‐PCR amplification of BAC and PAC clones
- A high-throughput gene expression analysis technique using competitive PCR and matrix-assisted laser desorption ionization time-of-flight MS
Cited by
- Functional analysis of human enhancers using the zebrafish embryo
- Chromatin Immunoprecipitation in Adult Zebrafish Red Cells
- Identification and Characterization of Novel Sir3/MeCP2-Chromatin Interactions
- Interactions of transcription factors with chromatin.
- Ancient roles of non-coding RNAs in eukaryotic evolution
- The role of noncoding RNA in thyroid cancer.
- Establishing a screen for enhancers active in Drosophila embryogenesis
- Exploiting Drosophila genetics to understand microRNA function and regulation
- Word-Based Characterization of the Bidirectional Promoters from the Human DNA-Repair Pathway
- New links to the pathogenesis of Crohn disease provided by genome-wide association scans
- Extrapolating ENCODE data to the whole human genome.
- Transcription induces strand-specific mutations at the 5' end of human genes.
- Phenotype-defining functions of multiple non-coding RNA pathways
- Revisiting the Saccharomyces cerevisiae predicted ORFeome.
- Genomic Organization of Zebrafish microRNAs
- Genome-wide nucleotide-level mammalian ancestor reconstruction.
- Annotation of tertiary interactions in RNA structures reveals variations and correlations.
- Sharing Data between LSDBs and Central Repositories
- Regulation of Ubx Expression by Epigenetic Enhancer Silencing in Response to Ubx Levels and Genetic Variation
- An overview of recent developments in genomics and associated statistical methods
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