Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1 alpha.
Explore this paper's citation graph
Summary
It is demonstrated that HIF-1alpha is a master regulator of cellular and developmental O2 homeostasis in Hif1a-/- embryos that manifested neural tube defects, cardiovascular malformations, and marked cell death within the cephalic mesenchyme.
- Type
- article
- Published
- 1998-01-15
- Cited by
- 2,640
- References
- 65
- Access
- Open access
- OpenAlex
- https://openalex.org/W2098972920
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:28854226
Keywords
Biology, HIF1A, Cell biology, Transcription factor, Embryonic stem cell
References
- Stabilization of vascular endothelial growth factor mRNA by hypoxia and hypoglycemia and coregulation with other ischemia-induced genes
- Characterization of a Subset of the Basic-Helix-Loop-Helix-PAS Superfamily That Interacts with Components of the Dioxin Signaling Pathway*
- HRF, a putative basic helix-loop-helix-PAS-domain transcription factor is closely related to hypoxia-inducible factor-1 alpha and developmentally expressed in blood vessels.
- Pit-1 determines cell types during development of the anterior pituitary gland. A model for transcriptional regulation of cell phenotypes in mammalian organogenesis.
- Oxygen(es) and the hypoxia-inducible factor-1.
- Manipulating the mouse embryo: A laboratory manual
- GATA-binding transcription factors in hematopoietic cells.
- Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1.
- The mouse gene for hypoxia-inducible factor-1alpha--genomic organization, expression and characterization of an alternative first exon and 5' flanking sequence.
- V-SRC induces expression of hypoxia-inducible factor 1 (HIF-1) and transcription of genes encoding vascular endothelial growth factor and enolase 1: involvement of HIF-1 in tumor progression.
- The Mouse Gene for Vascular Endothelial Growth Factor
- Teratocarcinomas and embryonic stem cells : a practical approach
- cDNA cloning and tissue-specific expression of a novel basic helix-loop-helix/PAS factor (Arnt2) with close sequence similarity to the aryl hydrocarbon receptor nuclear translocator (Arnt)
- Vascular endothelial cell lineage-specific promoter in transgenic mice.
- The murine Sim-2 gene product inhibits transcription by active repression and functional interference
- Hypoxia-inducible factor 1 levels vary exponentially over a physiologically relevant range of O2 tension.
- Activation of Hypoxia-inducible Factor-1; Definition of Regulatory Domains within the α Subunit*
- A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1alpha regulates the VEGF expression and is potentially involved in lung and vascular development.
- Pericyte loss and microaneurysm formation in PDGF-B-deficient mice.
- The MyoD family and myogenesis: redundancy, networks, and thresholds.
Cited by
- Hypoxia Regulates β-Enolase and Pyruvate Kinase-M Promoters by Modulating Sp1/Sp3 Binding to a Conserved GC Element*
- The study of xenobiotic-metabolizing enzymes and their role in toxicity in vivo using targeted gene disruption.
- Human cytotrophoblast expression of the von Hippel-Lindau protein is downregulated during uterine invasion in situ and upregulated by hypoxia in vitro.
- Adriana and Luisa Castellucci Award lecture 2001. Hypoxia inducible factor-1: oxygen regulation of trophoblast differentiation in normal and pre-eclamptic pregnancies--a review.
- Signal transduction to hypoxia-inducible factor 1.
- Podocyte expression of hypoxia-inducible factor (HIF)-1 and HIF-2 during glomerular development.
- Chronic Hypoxia in Development Selectively Alters the Activities of Key Enzymes of Glucose Oxidative Metabolism in Brain Regions
- Correlation between VEGF and HIF-1alpha expression in human oral squamous cell carcinoma.
- Hypoxia and hypoxia inducible factors (HIF) as important regulators of tumor physiology.
- Novel function of neuronal PAS domain protein 1 in erythropoietin expression in neuronal cells
- Constitutively active HIF-1alpha improves perfusion and arterial remodeling in an endovascular model of limb ischemia.
- Co‐option of an oral–aboral patterning mechanism to control left–right differentiation: the direct‐developing sea urchin Heliocidaris erythrogramma is sinistralized, not ventralized, by NiCl2
- Differential levels of tissue hypoxia in the developing chicken heart
- Identification and function of hypoxia-response genes in Drosophila melanogaster.
- Differential Regulation of the Transcriptional Activities of Hypoxia-Inducible Factor 1 Alpha (HIF-1α) and HIF-2α in Stem Cells
- Regulation of angiogenesis by hypoxia-inducible factor 1.
- The hypoxic inducible stress response as a target for cancer drug discovery.
- Oxidative stress in glaucomatous neurodegeneration: mechanisms and consequences.
- Metabolism of the bovine cumulus-oocyte complex and influence on subsequent developmental competence.
- Cellular mechanisms associated with intermittent hypoxia.
Related papers
- Hypoxia-inducible factor 1 (HIF1A; HIF1); endothelial PAS domain protein 1 (EPAS1; HIF2A); hypoxia-inducible factor prolyl hydroxylase (EGLN2; HIF-PHD; EGLN)
- von Hippel–Lindau tumor suppressor (VHL); hypoxia-inducible factor 1 (HIF1A; HIF1)
- Hypoxia-inducible factor prolyl hydroxylase (HIF-PH; EGLN); hypoxia-inducible factor 1α (HIF1A; HIF1α)
- Mouse model of von Hippel-Lindau renal cancer driven by hypoxia-inducible factor 1α (HIF1A; HIF1α)
- Hypoxia-Inducible Factors in Physiology and Medicine
- von Hippel-Lindau Tumor Suppressor Protein and Hypoxia-Inducible Factor in Kidney Cancer
- Intermittent hypoxia enhances the expression of hypoxia inducible factor HIF1A through histone demethylation
- Hypoxia-inducible factors, hypoxia, and tumor angiogenesis