von Hippel-Lindau Tumor Suppressor Protein and Hypoxia-Inducible Factor in Kidney Cancer
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Summary
The current molecular understanding of the roles of HIF and pVHL in the development of VHL-associated clear-cell renal cell carcinoma (CC-RCC) is the focus of this review.
- Type
- review
- Published
- 2004-02-01
- Cited by
- 128
- References
- 154
- Access
- Open access
- OpenAlex
- https://openalex.org/W1996544487
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:28527230
Keywords
Cullin, HIF1A, Ubiquitin ligase, Hypoxia-inducible factors, Ubiquitin
References
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- Rbx1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligase.
- Ubiquitin‐mediated proteolysis: biological regulation via destruction
- Molecular characterization and chromosomal localization of a third alpha-class hypoxia inducible factor subunit, HIF3alpha.
- Expression pattern of the von Hippel-Lindau protein in human tissues.
- Allelic deletions of the VHL gene detected in multiple microscopic clear cell renal lesions in von Hippel-Lindau disease patients.
- Loss of heterozygosity and somatic mutations of the VHL tumor suppressor gene in sporadic cerebellar hemangioblastomas.
- Cellular proteins that bind the von Hippel-Lindau disease gene product: mapping of binding domains and the effect of missense mutations.
- von Hippel-Lindau gene-mediated growth suppression and induction of differentiation in renal cell carcinoma cells grown as multicellular tumor spheroids.
- Von Hippel-Lindau disease
- cDNA cloning and tissue-specific expression of a novel basic helix-loop-helix/PAS factor (Arnt2) with close sequence similarity to the aryl hydrocarbon receptor nuclear translocator (Arnt)
- Induction of endothelial PAS domain protein-1 by hypoxia: characterization and comparison with hypoxia-inducible factor-1alpha.
- Transforming growth factor alpha is a target for the von Hippel-Lindau tumor suppressor.
- Regulation of Hypoxia-Inducible mRNAs by the von Hippel-Lindau Tumor Suppressor Protein Requires Binding to Complexes Containing Elongins B/C and Cul2
- Expression of the Von Hippel-Lindau Tumor Suppressor Gene, VHL, in Human Fetal Kidney and During Mouse Embryogenesis
- Identification of cyclin D1 and other novel targets for the von Hippel-Lindau tumor suppressor gene by expression array analysis and investigation of cyclin D1 genotype as a modifier in von Hippel-Lindau disease.
- Loss of alleles of loci on the short arm of chromosome 3 in renal cell carcinoma
- Activation of Hypoxia-inducible Factor-1; Definition of Regulatory Domains within the α Subunit*
Cited by
- Influence of hypoxia induced by minimally invasive prostatectomy on gene expression: implications for biomarker analysis.
- Charakterisierung von MHC-I-Liganden zum Einsatz in der Patienten-individuellen Immuntherapie des Nierenzellkarzinoms
- Angiogenesis in human renal cell carcinoma : hypoxia, vascularity and prognosis
- Discovery and analysis of pancreatic adenocarcinoma genes using cDNA microarrays.
- Identification of metabolic genes essential for proliferation of clear cell Renal Cell Carcinoma (ccRCC) cells
- PACAP Modulates Expression of Hypoxia-Inducible Factors in Streptozotocin-Induced Diabetic Rat Retina
- Expression of HIF-1alpha and GLUT-1 in human xenograft tumors in immundeficient mice
- Functional analysis of the von Hippel-Lindau tumour suppressor in mice
- Molecular mechanisms of the Keap1–Nrf2 pathway in stress response and cancer evolution
- Strong Expression of Chemokine Receptor CXCR4 by Renal Cell Carcinoma Correlates with Advanced Disease
- Association of CXCL12 and CXCR4 gene polymorphisms with the susceptibility and prognosis of renal cell carcinoma.
- Mechanisms, indications and results of salvage systemic therapy for sporadic and von Hippel-Lindau related hemangioblastomas of the central nervous system.
- Novel kinase inhibitors in renal cell carcinoma: Progressive development of static agents
- Renal cell carcinoma: current status and emerging therapies.
- Sunitinib resistance in renal cell carcinoma
- Gene expression in archived newborn blood spots distinguishes infants who will later develop cerebral palsy from matched controls
- Hypoxia and the hypoxia-inducible-factor pathway in glioma growth and angiogenesis.
- Role of VHL gene mutation in human renal cell carcinoma
- Somatic Pairing of Chromosome 19 in Renal Oncocytoma Is Associated with Deregulated ELGN2-Mediated Oxygen-Sensing Response
- Identification of a microRNA panel for clear-cell kidney cancer.
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