Regulation Mechanisms and Signaling Pathways of Autophagy
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Summary
The current knowledge on the key genes composing the autophagy machinery in eukaryotes from yeast to mammalian cells and the signaling pathways that sense the status of different types of stress and induce autophagic for cell survival and homeostasis are presented.
- Type
- review
- Published
- 2009-11-17
- Cited by
- 3,663
- References
- 173
- Access
- Open access
- OpenAlex
- https://openalex.org/W2096308078
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:24485956
Keywords
Autophagy, Biology, Cell biology, Neurodegeneration, Vacuole
References
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- Microtubules Facilitate Autophagosome Formation and Fusion of Autophagosomes with Endosomes
- Accumulation of autophagic vacuoles and cardiomyopathy in LAMP-2-deficient mice
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- Tor-Mediated Induction of Autophagy via an Apg1 Protein Kinase Complex
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- Two Distinct Vps34 Phosphatidylinositol 3–Kinase Complexes Function in Autophagy and Carboxypeptidase Y Sorting inSaccharomyces cerevisiae
- Host Cell Autophagy Is Induced by Toxoplasma gondii and Contributes to Parasite Growth*
- hVps34 Is a Nutrient-regulated Lipid Kinase Required for Activation of p70 S6 Kinase*
- NIX is required for programmed mitochondrial clearance during reticulocyte maturation
- HDAC6 rescues neurodegeneration and provides an essential link between autophagy and the UPS
- Cooperative Binding of the Cytoplasm to Vacuole Targeting Pathway Proteins, Cvt13 and Cvt20, to Phosphatidylinositol 3-Phosphate at the Pre-autophagosomal Structure Is Required for Selective Autophagy*
Cited by
- Oleanolic acid but not ursolic acid induces cell death in HepG2 cells under starvation-induced autophagy
- High-throughput ectopic expression screen for tamoxifen resistance identifies an atypical kinase that blocks autophagy
- cAMP induces autophagy via a novel pathway involving ERK, cyclin E and Beclin 1
- Molecular machinery of macroautophagy and its deregulation in diseases.
- Impact of the Autophagy Machinery on Hepatitis C Virus Infection
- Functional analysis of glutathione and autophagy in response to oxidative stress
- Newcastle disease virus triggers autophagy in U251 glioma cells to enhance virus replication
- Disruption and therapeutic rescue of autophagy in a human neuronal model of Niemann Pick type C1.
- In vivo imaging and quantitative monitoring of autophagic flux in tobacco BY-2 cells
- Apoptosis and necrosis: two different outcomes of cigarette smoke condensate-induced endothelial cell death
- Inducer of heme oxygenase‐1 cobalt protoporphyrin accelerates autophagy and suppresses oxidative damages during lipopolysaccharide treatment in rat liver
- Ras1CA-upregulated BCPI inhibits cathepsin activity to prevent tissue destruction of the Bombyx posterior silk gland.
- Selective Autophagy: talking with the UPS
- PTHrP Expression in Human MDA-MB-231 Breast Cancer Cells Is Critical for Tumor Growth and Survival and Osteoblast Inhibition
- Autophagy, a novel target for chemotherapeutic intervention of thyroid cancer
- Regulation of Autophagic Activation by Rta of Epstein-Barr Virus via the Extracellular Signal-Regulated Kinase Pathway
- Insects recycle endosymbionts when the benefit is over.
- miR-143 inhibits cell proliferation by targeting autophagy-related 2B in non-small cell lung cancer H1299 cells.
- The cell cycle regulator ecdysoneless cooperates with H-Ras to promote oncogenic transformation of human mammary epithelial cells
- Markers of autophagy are adapted to hyperglycaemia in skeletal muscle in type 2 diabetes
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