The vacuolar shapes of ageing: From function to morphology.
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Summary
The multiple roles of the vacuole during ageing are discussed, ranging from vacuolar dynamics and acidification as determinants of lifespan to the function of this organelle as waste bin, recycling facility, nutrient reservoir and integrator of nutrient signalling.
- Type
- review
- Published
- 2019-05-01
- Cited by
- 50
- References
- 149
- Access
- Open access
- OpenAlex
- https://openalex.org/W2917759590
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:73465676
Keywords
Vacuole, Organelle, Ageing, Cell biology, Lysosome
References
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- Extrachromosomal rDNA circles--a cause of aging in yeast.
- Need an ESCRT for autophagosomal maturation?
- Eaten alive: a history of macroautophagy
- Mitophagy Plays an Essential Role in Reducing Mitochondrial Production of Reactive Oxygen Species and Mutation of Mitochondrial DNA by Maintaining Mitochondrial Quantity and Quality in Yeast*
- A role for yeast oxysterol-binding protein homologs in endocytosis and in the maintenance of intracellular sterol-lipid distribution
- Superoxide is the major reactive oxygen species regulating autophagy
Cited by
- Acetyl-CoA carboxylase 1–dependent lipogenesis promotes autophagy downstream of AMPK
- A Review of Plant Vacuoles: Formation, Located Proteins, and Functions
- Microbial ageing and longevity
- Role of sorting nexin PaATG24 in autophagy, aging and development of Podospora anserina.
- Role of the ESCRT Pathway in Laccase Trafficking and Virulence of Cryptococcus neoformans
- Changes in the Ultrastructure of Candida albicans Treated with Cationic Peptides
- Closing the Gap: Membrane Contact Sites in the Regulation of Autophagy
- A kinase cascade on the yeast lysosomal vacuole regulates its membrane dynamics: conserved kinase Env7 is phosphorylated by casein kinase Yck3
- The V-ATPase regulates localization of the TRP Ca2+ channel Yvc1 in response to oxidative stress in Candida albicans.
- Barcode sequencing and a high-throughput assay for chronological lifespan uncover ageing-associated genes in fission yeast
- Oxidative Stress Causes Vacuolar Fragmentation in the Human Fungal Pathogen Cryptococcus neoformans
- Phosphate Restriction Promotes Longevity via Activation of Autophagy and the Multivesicular Body Pathway
- Sterol uptake by the NPC system in eukaryotes: a Saccharomyces cerevisiae perspective
- Replicative Aging Remodels Cell Wall and is Associated with Increased Intracellular Trafficking in Human Pathogenic Yeasts
- Replicative Aging Remodels the Cell Wall and Is Associated with Increased Intracellular Trafficking in Human Pathogenic Yeasts
- Evaluation of In Situ Antiaging Activity in Saccharomyces cerevisiae BY611 Yeast Cells Treated with Polyalthia longifolia Leaf Methanolic Extract (PLME) Using Different Microscopic Approaches: A Morphology-Based Evaluation
- The Plant V-ATPase
- Actin-Related Protein 4 and Linker Histone Sustain Yeast Replicative Ageing
- Multidimensional proteomics identifies molecular trajectories of cellular aging and rejuvenation
- Adaptive responses of yeast strains tolerant to acidic pH, acetate, and supraoptimal temperature
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