Interleukin-23 Promotes a Distinct CD4 T Cell Activation State Characterized by the Production of Interleukin-17*
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Summary
Evidence is presented that murine IL-23, which is produced by activated dendritic cells, acts on memory T cells, resulting in elevated IL-17 secretion, which suggests that during a secondary immune response, IL- 23 can promote an activation state with features distinct from the well characterized Th1 and Th2 profiles.
- Type
- article
- Published
- 2003-01-17
- Cited by
- 2,056
- References
- 32
- Access
- Open access
- OpenAlex
- https://openalex.org/W2090197666
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:43645471
Keywords
Cytokine, Immunology, Interleukin 17, Interleukin 23, Interleukin 10
References
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- Down-regulation of homing receptors after T cell activation.
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- IL-17 stimulates the production and expression of proinflammatory cytokines, IL-beta and TNF-alpha, by human macrophages.
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- Airway neutrophils and interleukin-17.
- IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis.
- IL‐17s adopt a cystine knot fold: structure and activity of a novel cytokine, IL‐17F, and implications for receptor binding
Cited by
- Wolbachia endosymbiont of Onchocerca volvulus: driver of immunopathology and target for therapy
- Defining the Helper T Cell Contribution to Helicobacter pylori Gastritis
- Induction of Experimental Autoimmune Encephalomyelitis in IL-12 Receptor-β2-Deficient Mice: IL-12 Responsiveness Is Not Required in the Pathogenesis of Inflammatory Demyelination in the Central Nervous System1
- Dendritic cells in rheumatoid arthritis.
- IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6.
- IL-23 Is Increased in Dendritic Cells in Multiple Sclerosis and Down-Regulation of IL-23 by Antisense Oligos Increases Dendritic Cell IL-10 Production
- IL-17 family cytokines and the expanding diversity of effector T cell lineages.
- TPA induction leads to a Th17-like response in transgenic K14/VEGF mice: a novel in vivo screening model of psoriasis.
- Biologic therapy in Crohn's disease: state of the art
- Retinoid signals and Th17-mediated pathology.
- Differential IL-23 requirement for IL-22 and IL-17A production during innate immunity against Salmonella enterica serovar Enteritidis.
- The secreted form of p28 subunit of interleukin (IL)‐27 inhibits biological functions of IL‐27 and suppresses anti‐allogeneic immune responses
- Th17 cells: positive or negative role in tumor?
- Alfacalcidol treatment restores derailed immune-regulation in patients with undifferentiated connective tissue disease.
- Human RORγt+ TH17 cells preferentially differentiate from naive FOXP3+Treg in the presence of lineage-specific polarizing factors
- Efficacy and safety of ABT-874, a monoclonal anti-interleukin 12/23 antibody, for the treatment of chronic plaque psoriasis: 36-week observation/retreatment and 60-week open-label extension phases of a randomized phase II trial.
- Monoclonal antibodies in multiple sclerosis treatment: current and future steps
- Marked Induction of c-Maf Protein during Th17 Cell Differentiation and Its Implication in Memory Th Cell Development*
- The role of SNARE proteins in CD4+ T-helper cell subsets
- Non-tuberculous mycobacteria and their surface lipids efficiently induced IL-17 production in human T cells.
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