Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12.
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Summary
Human IL-23 stimulates IFN-gamma production and proliferation in PHA blast T cells, as well as in CD45RO (memory) T cells and induces strong proliferation of mouse memory T cells.
- Type
- article
- Published
- 2000-11-01
- Cited by
- 3,023
- References
- 49
- Access
- Open access
- OpenAlex
- https://openalex.org/W2087905758
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:34415119
Keywords
Biology, Cytokine, Cell biology, Protein subunit, Secretion
References
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- A bioactive designer cytokine for human hematopoietic progenitor cell expansion
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- From immunogenic mechanisms to novel therapeutic approaches in inflammatory bowel disease.
- Defining the Helper T Cell Contribution to Helicobacter pylori Gastritis
- ATP-mediated killing of intracellular mycobacteria by macrophages is a P2X(7)-dependent process inducing bacterial death by phagosome-lysosome fusion.
- Experimental models of mucosal inflammation.
- Experimental autoimmune encephalomyelitis: Cytokines, effector t cells, and antigen-presenting cells in a prototypical th1-mediated autoimmune disease
- Induction of Experimental Autoimmune Encephalomyelitis in IL-12 Receptor-β2-Deficient Mice: IL-12 Responsiveness Is Not Required in the Pathogenesis of Inflammatory Demyelination in the Central Nervous System1
- Mucosal Immunity in Crohn's Disease
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- TLR Ligands Can Activate Dendritic Cells to Provide a MyD88-Dependent Negative Signal for Th2 Cell Development1
- Analysis of the activation profile of dendritic cells derived from the bone marrow of interleukin‐12/interleukin‐23‐deficient mice
- Preferential production of the IL‐12(p40)/IL‐23(p19) heterodimer by dendritic cells from human newborns
- Agents against cytokine synthesis or receptors.
- IL-12 deficiency transiently improves viral clearance during the late phase of respiratory tract infection with influenza A virus in mice
- IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6.
- IL-23 Is Increased in Dendritic Cells in Multiple Sclerosis and Down-Regulation of IL-23 by Antisense Oligos Increases Dendritic Cell IL-10 Production
- IL-17 family cytokines and the expanding diversity of effector T cell lineages.
- The secreted form of p28 subunit of interleukin (IL)‐27 inhibits biological functions of IL‐27 and suppresses anti‐allogeneic immune responses
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